Results 141 to 150 of about 661,734 (412)

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo   +11 more
wiley   +1 more source

Profile of retinal vasculitis in a tertiary eye care center in Eastern India

open access: yesIndian Journal of Ophthalmology, 2011
Aims: To provide a fact file on the etiology, clinical presentations and management of retinal vasculitis in Eastern India. Materials and Methods: Retrospective, record based analysis of retinal vasculitis cases in a tertiary care center in Eastern India
Kumar Saurabh   +3 more
doaj   +1 more source

Modeling Human Erythrocyte Shape and Size Abnormalities [PDF]

open access: yesarXiv, 2005
We present simple parametric equations in terms of Jacobi elliptic functions that provide a realistic model of the shape of human normal erythrocytes as well as of variations in size (anisocytosis) and shape (poikilocytosis) thereof. We illustrate our results with parameterizations of microcytes, macrocytes and stomatocytes, and show the applicability ...
arxiv  

Skin erythrodiapedesis during chronic venous disorders [PDF]

open access: yes, 2011
Background: Extravasation of erythrocytes (erythrodiapedesis [ED]) is currently included among causes of skin damage in legs with chronic venous disorders (CVD) and ascribed to venular hypertension.
Alberto Caggiati   +3 more
core   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq   +4 more
wiley   +1 more source

Erythrocyte microRNAs show biomarker potential and implicate multiple sclerosis susceptibility genes

open access: yesClinical and Translational Medicine, 2020
Background Multiple sclerosis is a demyelinating autoimmune disease, for which there is no blood‐borne biomarker. Erythrocytes may provide a source of such biomarkers as they contain microRNAs. MicroRNAs regulate protein translation through complementary
Kira Groen   +4 more
doaj   +1 more source

Shape changes and motion of a vesicle in a fluid using a lattice Boltzmann model [PDF]

open access: yesarXiv, 2006
We study the deformation and motion of an erythrocyte in fluid flows via a lattice Boltzmann method. To this purpose, the bending rigidity and the elastic modulus of isotropic dilation are introduced and incorporated with the lattice Boltzmann simulation, and the membrane-flow interactions on both sides of the membrane are carefully examined.
arxiv  

Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors. [PDF]

open access: yes, 1987
We have examined receptors mediating phagocytosis of the intracellular bacterial pathogen, Legionella pneumophila. Three mAbs against the type 3 complement receptor (CR3), which recognizes C3bi, inhibit adherence of L.
Horwitz, MA, Payne, NR
core  

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

open access: yesAdvanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren   +13 more
wiley   +1 more source

Double anterior chamber in a patient with glaucoma and microspherophakia

open access: yesIndian Journal of Ophthalmology, 2011
We report the case of a 16-year-old woman with microspherophakia and secondary open angle glaucoma. The patient presented with a membrane dividing the anterior chamber into two segments without edema or Descemet′s membrane detachment.
Hamid Khakshoor   +4 more
doaj   +1 more source

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