Results 41 to 50 of about 99,664 (224)
Microbiology Spectrum, 2021 Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, causes severe invasive infections, including meningitis and bacteremia. The widespread use of macrolides has been reported to increase the prevalence of macrolide-resistant ...
Hisanori Domon +8 more
doaj +1 more source
Macrocyclization of ω‐Isocyano Aldehydes
Angewandte Chemie, EarlyView.The ω‐isocyano aldehydes readily undergo cyclization to afford α‐acyloxy, α‐hydroxy, α‐acetamido, and α‐keto macrolactams, as well as tetrazole‐fused macrocycles, via C(sp3)─C(sp2) bond formation, providing access to diverse α‐functionalized medium‐sized lactams and macrolactams. ABSTRACT Medium‐sized rings and macrocycles constitute a privileged class
Baochao Yang +4 more
wiley +2 more sources
Frontiers in MicrobiologyThe widespread presence of methicillin-resistant Staphylococcus aureus (MRSA) severely threatens convenient therapeutic options in the postantibiotic era.
Yinuo Zou +9 more
doaj +1 more source
Frontiers in Microbiology, 2019 Some terrestrial cyanobacteria can acclimate to and then utilize far-red light (FRL; λ = 700–800 nm) to perform oxygenic photosynthesis through a process called Far-Red Light Photoacclimation (FaRLiP). During FaRLiP, cells synthesize chlorophylls (Chl) d
Ming-Yang Ho +4 more
doaj +1 more source
Foods, 2021 Nontargeted analysis can be used for the rapid screening and confirmatory analysis of veterinary drugs and their metabolites, which are important for the comprehensive safety evaluation of animal-derived foods.
Bo Wang +5 more
doaj +1 more source
A rare instance of Ogilvie syndrome in a pediatric patient with a complex medical history: A case report [PDF]
JPGN RepAbstract Acute colonic pseudo‐obstruction or Ogilvie's syndrome is an acute dilatation of the large bowel without an obstructive lesion. Symptoms include abdominal distension, nausea and vomiting, constipation, and occasional dyspnea. The disorder most commonly involves the cecum and right colon and is most frequently seen in male patients above the ...
Lampe K, Sarata V, Har A, Zapata F.
europepmc +2 more sources
Biomedicines, 2022 The fast elimination of drugs from the cornea is one of many challenges associated with the topical administration of conventional dosage forms. The present manuscript aimed to prepare modified-release inserts containing erythromycin (ERY) to enhance ...
Shahla Mirzaeei +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Bacillus subtilis is engineered to produce cell‐adhesive biofilms by functionalization of its biofilm scaffold protein TasA with a cell‐adhesion sequence. Living bacteria within the biofilm are also engineered to secrete growth factors and natively produce antimicrobial peptides (AMPs), resulting in a cell‐adhesive, antimicrobial, and growth factor ...
Mélanie Côté‐Cyr +3 more
wiley +1 more source
Antimicrobial Resistance in Periodontal Disease: Rethinking Adjunctive Therapy in the Metagenomics Era, the Pressing Need for Precision Treatment and Periodontal Resistome Mapping. [PDF]
J Cell Mol MedABSTRACT Systemic antibiotics are effective when used as adjunctive therapy in the treatment of periodontitis; however, their use must be balanced against antimicrobial resistance, which is a major threat to global public health. This review provides an expert synthesis of the literature and a field‐level overview of antimicrobial resistance in ...
Alghafri M +3 more
europepmc +2 more sources
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source