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Rethinking EPO: A Paradigm Shift in Oncology? [PDF]

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Ferrero JM   +4 more
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Erythropoietin

British Medical Bulletin, 1989
Erythropoietin mRNA is detected primarily in kidney peritubular cells in response to hypoxia, and this tissue is the major adult source of the hormone. Erythropoietin can be assayed by in vivo or in vitro biological methods, or by radioimmunoassay, but only the in vivo assay can distinguish the most biologically active forms.
E D, Zanjani, J L, Ascensao
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Erythropoietin

Comprehensive Physiology, 2011
AbstractThe hormone erythropoietin (Epo) is the main humoral regulator of erythropoiesis. It binds to specific receptors belonging to the cytokine receptor superfamily. Epo stimulates proliferation and differentiation of erythroid precursor cells, but may also bind to and exert some additional effects in nonhemopoietic tissues. It is mainly produced in
Wenger, R H, Kurtz, A
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Erythropoietin

Leukemia Research, 1990
The remarkable capacity of the bone marrow to compensate for blood loss and for reduced atmospheric oxygen tension has been found to be mediated by a renal hormone, named erythropoietin. It is produced by peritubular interstitial cells in response to renal hypoxia, but molecular engineering has permitted large scale production of an identical ...
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Erythropoietin and Erythropoietin Receptor

Growth Factors, 1999
(1999). Erythropoietin and Erythropoietin Receptor. Growth Factors: Vol. 17, No. 1, pp. 25-35.
P A, Tilbrook, S P, Klinken
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Erythropoietin

Journal of Endocrinological Investigation, 2003
This article summarizes recent advances in understanding the production and action of the hormone erythropoietin (Epo) with respect to high altitude physiology and sports medicine. Hypoxia is the main stimulus for Epo gene expression. An O2-labile protein (hypoxia-inducible factor 1, HIF-1) has been identified that is hydroxylated and degraded under ...
openaire   +3 more sources

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