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Erythropoietin

Leukemia Research, 1990
The remarkable capacity of the bone marrow to compensate for blood loss and for reduced atmospheric oxygen tension has been found to be mediated by a renal hormone, named erythropoietin. It is produced by peritubular interstitial cells in response to renal hypoxia, but molecular engineering has permitted large scale production of an identical ...
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Erythropoietin and Erythropoietin Receptor

Growth Factors, 1999
(1999). Erythropoietin and Erythropoietin Receptor. Growth Factors: Vol. 17, No. 1, pp. 25-35.
P A, Tilbrook, S P, Klinken
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Erythropoietin

Journal of Endocrinological Investigation, 2003
This article summarizes recent advances in understanding the production and action of the hormone erythropoietin (Epo) with respect to high altitude physiology and sports medicine. Hypoxia is the main stimulus for Epo gene expression. An O2-labile protein (hypoxia-inducible factor 1, HIF-1) has been identified that is hydroxylated and degraded under ...
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ERYTHROPOIETINE

Pediatrics, 1959
ERYTHROPOIETINE is a protein, capable of stimulating erythrocyte production, which is found in the plasma of animals subjected to hypoxia or following the administration of cobalt. Sufficient data have been accumulated in the more common hematologic disorders to draw some tentative conclusions about its etiologic and therapeutic significance in ...
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Erythropoietin pharmacology

Clinical and Translational Oncology, 2007
Anaemia is a frequent complication in cancer patients and may be multifactorial in origin. Treatment with recombinant human erythropoietin (rHuEPO) is an alternative to red blood cell transfusion. The evidence from clinical trials has established that patients with chemotherapy-induced anaemia with a haemoglobin concentration below 10 g/dl benefit from
J M, Jurado García   +3 more
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Erythropoietin

Archives of Internal Medicine, 1973
Erythropoietin (Epo), the first growth factor to be discovered, is an endocrine hormone produced by specialized renal cells. The rate of Epo production is determined primarily by the oxygen demands of these renal cells relative to their oxygen supply.
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Erythropoietin

Blut, 1976
Abstract Epo was purified from the urine of anaemic patients(Miyake et al. 1977), and the amino acid sequence derived from the purified protein {Lai et al. 1986) led to the cloning of the human epo gene {Lin et al. 1985; Jacobs et al. 1985).
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Erythropoietin and Erythropoietin Receptor in Colorectal Cancer

International Journal of Surgical Pathology, 2008
Erythropoietin via erythropoietin receptor effectively prevents anemia, giving reasons for a clinical use of erythropoietin in patients with colorectal cancers. However, erythropoietin seems to promote survival of the neoplastic cells in hypoxic environment.
Anna M, Chabowska   +5 more
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