Results 61 to 70 of about 434,485 (278)

Overview of the CCI+SSS project

, 2019
International audienceSea Surface Salinity (SSS) is an Essential Climate Variable (ECV) that plays a fundamental role in the density-driven global ocean circulation, the water cycle, and climate.
Catany, Rafael, Reul, Nicolas, Boutin, Jacqueline, Consortium, Cci+sss   +3 more
core   +3 more sources

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Assessment of High-Resolution Surface Soil Moisture Products over the Qinghai–Tibet Plateau for 2009–2017

Atmosphere, 2023
The surface soil moisture over the Qinghai–Tibet Plateau (QTP) has an important impact on the weather and climate of East Asia. Under climate warming, the imbalance of solid–liquid water of QTP has become a research hotspot, but the surface soil moisture
Dongjun Lin, Xing Yuan, Binghao Jia, Peng Ji   +3 more
doaj   +1 more source

Impact of Laparoscopic Liver Resection on Long‐Term Outcomes and Non‐Liver‐Related Mortality in Elderly Patients With Primary Hepatocellular Carcinoma: A Multicenter Propensity Score‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
In this multicenter, propensity score–matched study of elderly patients with primary hepatocellular carcinoma, we compared long‐term cause‐specific mortality between laparoscopic (LLR) and open liver resection (OLR) using a competing‐risks framework. Among patients aged ≥ 80 years, LLR was associated with a lower 5‐year cumulative incidence of death ...
Yukio Tokumitsu, Hidenori Takahashi, Yuki Nakagami, Toru Hisaka, Hiromitsu Hayashi, Tomoharu Yoshizumi, Norifumi Harimoto, Takao Ide, Yoichi Yamasaki, Atsushi Miyoshi, Yuichi Endo, Tamotsu Kuroki, Atsushi Nanashima, Masahiko Sakoda, Tohru Utsunomiya, Kohji Okamoto, Masatoshi Kajiwara, Mitsuhisa Takatsuki, Toru Beppu, Susumu Eguchi   +19 more
wiley   +1 more source

Identifying the Spatial Heterogeneity and Driving Factors of Satellite-Based and Hydrologically Modeled Profile Soil Moisture

Remote Sensing
Profile soil moisture (PSM), the soil water content in the whole soil layer, directly controls the major processes related to biological interaction, vegetation growth, and runoff generation.
Han Yang, Xiaoqi Zhang, Zhe Yuan, Bin Xu, Junjun Huo   +4 more
doaj   +1 more source

Neuromuscular Electric Stimulation Improves Early Isometric Knee Strength After Anterior Cruciate Ligament Reconstruction and Repair: A Meta‐analysis of Randomized Controlled Trials

Arthroscopy, EarlyView.
Purpose To assess the effectiveness of neuromuscular electrical stimulation (NMES) on quadriceps strength and knee function after anterior cruciate ligament surgery. Methods A comprehensive search of PubMed, Ovid MEDLINE, and Embase from inception until February 2025 was conducted.
Anser Daud, Darius Luke Lameire, Geoffrey William Schemitsch, Daniel Burke Whelan, Tim Dwyer, John Theodoropoulos, Jaskarndip Chahal   +6 more
wiley   +1 more source

Updated COVID‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions

Arthritis &Rheumatology, EarlyView.
Objective We aimed to assess the association between COVID‐19 vaccination status and COVID‐19‐related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECMO), and death in people with autoimmune rheumatic conditions. Methods We conducted a retrospective cohort study using National Clinical Cohort Collaborative
Lesley E. Jackson, A. Jerrod Anzalone, Kenneth G. Saag, Rahima Begum, AKM F. Rahman, Namrata Singh, Kaleb Michaud, Jasvinder A. Singh, Rena C. Patel, Maria I. Danila, on behalf of the National Clinical Cohort Collaborative Consortium, Adam B. Wilcox, Adam M. Lee, Alexis Graves, Alfred (Jerrod) Anzalone, Amin Manna, Amit Saha, Amy Olex, Andrea Zhou, Andrew E. Williams, Andrew M. Southerland, Andrew T. Girvin, Anita Walden, Anjali Sharathkumar, Benjamin Amor, Benjamin Bates, Brian Hendricks, Brijesh Patel, G. Caleb Alexander, Carolyn T. Bramante, Cavin Ward‐Caviness, Charisse Madlock‐Brown, Christine Suver, Christopher G. Chute, Christopher Dillon, Chunlei Wu, Clare Schmitt, Cliff Takemoto, Dan Housman, Davera Gabriel, David A. Eichmann, Diego Mazzotti, Donald E. Brown, Eilis Boudreau, Elaine L. Hill, Emily Carlson Marti, Emily R. Pfaff, Evan French, Farrukh M. Koraishy, Federico Mariona, Fred Prior, George Sokos, Greg Martin, Harold P. Lehmann, Heidi Spratt, Hemalkumar B. Mehta, J. W. Awori Hayanga, Jami Pincavitch, Jaylyn Clark, Jeremy Richard Harper, Jessica Yasmine Islam, Jin Ge, Joel Gagnier, Johanna J. Loomba, John B. Buse, Jomol Mathew, Joni L. Rutter, Julie A. McMurry, Justin Guinney, Justin Starren, Karen Crowley, Katie Rebecca Bradwell, Kellie M. Walters, Ken Wilkins, Kenneth R. Gersing, Kenrick Cato, Kimberly Murray, Kristin Kostka, Lavance Northington, Lee Pyles, Lesley Cottrell, Lili M. Portilla, Mariam Deacy, Mark M. Bissell, Marshall Clark, Mary Emmett, Matvey B. Palchuk, Melissa A. Haendel, Meredith Adams, Meredith Temple‐O'Connor, Michael G. Kurilla, Michele Morris, Nasia Safdar, Nicole Garbarini, Noha Sharafeldin, Ofer Sadan, Patricia A. Francis, Penny Wung Burgoon, Philip R. O. Payne, Randeep Jawa, Rebecca Erwin‐Cohen, Rena C. Patel, Richard A. Moffitt, Richard L. Zhu, Rishikesan Kamaleswaran, Robert Hurley, Robert T. Miller, Saiju Pyarajan, Sam G. Michael, Samuel Bozzette, Sandeep K. Mallipattu, Satyanarayana Vedula, Scott Chapman, Shawn T. O'Neil, Soko Setoguchi, Stephanie S. Hong, Steven G. Johnson, Tellen D. Bennett, Tiffany J. Callahan, Umit Topaloglu, Valery Gordon, Vignesh Subbian, Warren A. Kibbe, Wenndy Hernandez, Will Beasley, Will Cooper, William Hillegass, Xiaohan Tanner Zhang   +127 more
wiley   +1 more source

Assimilating ESA CCI land surface temperature into the ORCHIDEE land surface model: insights from a multi-site study across Europe [PDF]

Hydrology and Earth System Sciences
Land surface temperature (LST) plays an essential role in water and energy exchanges between the Earth's surface and atmosphere. Recent advancements in high-quality satellite-derived LST data and land data assimilation systems present a unique ...
L.-E. Olivera-Guerra, C. Ottlé, N. Raoult, P. Peylin   +3 more
doaj   +1 more source

Impact of extended insurance coverage on survival outcomes among patients with metastatic colorectal cancer in Taiwan

British Journal of Clinical Pharmacology, EarlyView.
Aims Predetermined treatment duration limits (PTDLs) are often used by Taiwan's National Health Insurance Administration to contain healthcare costs, but they may compromise patient outcomes. Therefore, we studied Taiwan's 2017 extension of the bevacizumab PTDL from 24 to 36 weeks in metastatic colorectal cancer (mCRC) to evaluate whether prolonged ...
Wei‐Ming Huang, Chen‐Han Chueh, Chien‐Yu Tseng, Christopher N. Kaufmann, Earl J. Morris, Chiao‐En Wu, Yi‐Wen Tsai   +6 more
wiley   +1 more source