Results 121 to 130 of about 408,399 (236)

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Congestion, decongestion, renal function and diuretics in (ESC) heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 730-732, April 2025.
Jan Biegus, Piort Gajewski, Piotr Ponikowski   +2 more
wiley   +1 more source

Is posttraumatic stress disorder specific to drug‐resistant epilepsy or a common feature of chronic disease? A comparative study with atrial fibrillation and type 1 diabetes

Epilepsia, EarlyView.
Abstract Objective Posttraumatic stress disorder (PTSD) is more prevalent in epilepsy than in the general population. However, it remains unclear whether this association is specific to epilepsy or a broader consequence of experiencing unpredictable acute episodes within chronic diseases.
Lisa‐Dounia Soncin, Capucine Rodet, Mina Aboulmakarim, Bernard Giusiano, Marie Arthuis, Jean‐Claude Deharo, Patrice Darmon, Olivia Ronsin, Sylvane Faure, Fabrice Bartolomei   +9 more
wiley   +1 more source

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source

Clinical relevance of double‐arm blood pressure measurement and prevalence of clinically important inter‐arm blood pressure differences in Indian Primary Care

The Journal of Clinical Hypertension, Accepted Article., 2022
Abstract Hypertension guidelines recommend measuring blood pressure (BP) in both arms at least once. However, this is seldom done due to uncertainties regarding measurement procedure and the implications of finding a clinically important inter‐arm BP difference (IAD).
Gurpreet S. Wander, Sinead T.J. McDonagh, M. Srinivasa Rao, R. Alagesan, JC Mohan, Ajit Bhagwat, AK Pancholia, M. Viswanathan, Manoj Bhavrilal Chopda, A Purnanand, PLN kapardhi, Arun R Vadavi, R Selvaraj, Pankaj Aneja, Suhas Hardas, Neil Bordoloi, N Sivakadaksham, Christopher E goswami, Christopher E Clark, Willem J. Verberk   +19 more
wiley   +1 more source

π‐Expanded Fluoranthenes as Chromophores With Tailored Properties

Helvetica Chimica Acta, EarlyView.
A series of π‐expanded fluoranthene scaffolds selectively functionalized with electron donors and acceptors were synthesized. The evolution of the structural, optoelectronic, and redox properties in relation to substitution and cyclization was comprehensively studied both in experiment and in theory. The results identify the compounds as highly tunable
Silas C. Eiden, Erik Misselwitz, John Bergner, Frank Rominger, Milan Kivala   +4 more
wiley   +1 more source

C60 fullerene improves the rat musculus soleus contractile activity after ischemic stroke-related peptide administration

Materials Research Express
The results of our previous study revealed that ischemic stroke (IS) is accompanied by an increased concentration of plasma peptides, furthermore, circulatory IS-related peptides may trigger the progression of IS-associated complications. The goal of the
Dmytro Nozdrenko, Оlexandr Bezuh, Iryna Dmytruk, Tetiana Halenova, Nataliia Raksha, Tetiana Vovk, Olexii Savchuk, Liudmyla Ostapchenko, Yuriy Prylutskyy   +8 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Recomendações Europeias para a prevenção da doença cardiovascular na prática clínica (versão de 2012)

Revista Portuguesa de Cardiologia, 2013
Joep Perk, Guy De Backer, Helmut Gohlke, Ian Graham, Zeljko Reiner, W.M. Monique Verschuren, Christian Albus, Pascale Benlian, Gudrun Boysen, Renata Cifkova, Christi Deaton, Shah Ebrahim, Miles Fisher, Giuseppe Germano, Richard Hobbs, Arno Hoes, Sehnaz Karadeniz, Alessandro Mezzani, Eva Prescott, Lars Ryden, Martin Scherer, Mikko Syvänne, Wilma J.M. Scholte Op Reimer, Christiaan Vrints, David Wood, Jose Luis Zamorano, Faiez Zannad   +26 more
doaj   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source