Results 61 to 70 of about 408,399 (236)

Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants [PDF]

, 2019
Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs
AC Fahed, AC Michell, B Bamforth, B Li, B Xu, BG Bruneau, C-M Chen, CA Eisenberg, D Fraidenraich, D Sabour, ED Cohen, EY Chen, H Mori, H Thomas, I Pacheco-Leyva, J Bakkers, JA Bisson, JA Gaspar, JP Pinto, JPM Barbera, K Meganathan, KR Kranc, M Sahara, M Xu, MV Kuleshov, P Andre, P Choudhry, P Hu, Q Li, S Bhattacharya, S Liu, S Mazzotta, S Sperling, S Ueno, S Zaidi, S-W Cha, SD Bamforth, ST MacDonald, ST MacDonald, T Tan, V Kouskoff, V Wagh, VK Khodiyar, WJ Weninger, Y Liu, Z Yin   +45 more
core   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

The formation of Haumea and its family via binary merging

Nature Communications, 2022
Formation of the Haumea family, the only collisional group of icy bodies in the Kuiper Belt, is debated. Here, the authors show that Haumea family can be explained as a results of binary merging near the end of Neptune’s orbital migration.
Benjamin Proudfoot, Darin Ragozzine
doaj   +1 more source

‘Anthropomorphic drones’ and colonized bodies: William Gibson’s the peripheral [PDF]

, 2016
William Gibson tends to write in trilogies, as his first nine novels show. These series – the Sprawl, the Bridge, and the Blue Ant trilogies – are set in three different time periods and are populated by characters who reappear from one book to the next.
Mcfarlane, Anna
core   +1 more source

Critical Limitations in Cryogenic Laser Cooling of Solids: Symmetry‐Related Fluorescence Trapping and Condensation‐Induced Parasitic Heating

Advanced Science, EarlyView.
This study uncovers two overlooked bottlenecks in cryogenic laser cooling of solids: symmetry‐driven fluorescence trapping and water vapor condensation. We demonstrate that breaking sample symmetry enhances fluorescence escape, while condensation dominates parasitic heating below 135 K.
Biao Zhong, Jiayi Zhang, Haodong Yang, Lianzhong Deng, Mauro Tonelli, Ercang Luo   +5 more
wiley   +1 more source

Actomyosin ATPase activity of skeletal muscles and the markers of tissue damage in the blood of rats under prolonged chronic alcoholization [PDF]

The Ukrainian Biochemical Journal, 2014
The activity of creatine kinase and indices of lipid metabolism in the blood and also actomyosin ATPase activity of skeletal muscles of rats under chronic 8-month alcohol abuse were investigated.
Yu. V. Tseyslyer, О. M. Podpalova, N. Е. Nurishchenko, V. S. Маrtyniuk   +3 more
doaj   +1 more source

The Little Galaxies that Could (Reionize the Universe): Predicting Faint End Slopes & Escape Fractions at z > 4

, 2017
The sources that reionized the universe are still unknown, but likely candidates are faint but numerous galaxies. In this paper we present results from running a high resolution, uniform volume simulation, the Vulcan, to predict the number densities of ...
Anderson, Lauren, Governato, Fabio, Karcher, Michael, Quinn, Tom, Wadsley, James   +4 more
core   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

Bacteriophage–derived double-stranded RNA (larifan) exerts variable effects on human blood monocytes depending on age and sex of donors [PDF]

The Ukrainian Biochemical Journal
To date, great attention is paid to sex and age differences in the therapeutic effectiveness of drugs, including those that impact the immune system.
R. Dovhyi , M. Rudyk, T. Serhiichuk, Yu. Yumyna, A. Dvukhriadkina, K. Ostrovska, D. Pjanova, L. Skivka   +7 more
doaj   +1 more source

The Spectral Slope and Escape Fraction of Bright Quasars at $z \sim 3.8$: the Contribution to the Cosmic UV Background [PDF]

, 2016
We use a sample of 1669 QSOs ...
Cristiani, Stefano, Fontanot, Fabio, Koothrappali, Rajesh R., Monaco, Pierluigi, Serrano, Luisa Maria, Vanzella, Eros   +5 more
core   +2 more sources