Results 61 to 70 of about 5,190,226 (209)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells

Cancer Science, EarlyView.
RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia, Fengming Xu, Tao Zhou, Pingping Wang, Huiping Chen, Jing Zhang, Xiaochen Yuan, Haoxun Xu, Yu Ouyang   +8 more
wiley   +1 more source

Management of grapevine trunk diseases: knowledge transfer, current strategies and innovative strategies adopted in Europe

Phytopathologia Mediterranea, 2018
Since the early 1990s, grapevine trunk diseases (GTDs) have posed threats for viticulture. Esca complex, Eutypa- and Botryosphaeria- diebacks, mostly detected in adult vineyards, are currently responsible for considerable economic losses in the main vine-
Vincenzo MONDELLO, Philippe LARIGNON, Josep ARMENGOL, Andreas KORTEKAMP, Kalman VACZY, Fanny PREZMAN, Eric SERRANO, Cecilia REGO, Laura MUGNAI, Florence FONTAINE   +9 more
doaj   +1 more source

ESCA Studies of N,N′-Thiobisamines and of Some of its Chromium Carbonyl Complexes [PDF]

Zeitschrift für Naturforschung B, 1988
Abstract The X-ray photoelectron spectra of some N,N′-thiobisamines and of two of its complexes with Cr(CO)5 have been studied. The S(2p) binding energies are found to correlate with the effective nuclear charge on the sulfur atom as well as with the double bond character of the S-N linkage.
G. González, C. Díaz, H. Binder
openaire   +1 more source

TRIM59 Drives Bladder Cancer Progression Through E3 Ligase‐Dependent K48‐Linked Degradation of PTRF

Cancer Science, EarlyView.
Schematic model of TRIM59‐driven BLCA progression through K48‐linked ubiquitination and proteasomal degradation of PTRF, leading to AKT activation and c‐Myc upregulation. ABSTRACT Tripartite motif‐containing 59 (TRIM59) is an E3 ubiquitin ligase implicated in multiple malignancies, but its role in bladder cancer (BLCA) remains incompletely understood ...
Junlin Gan, Xuesong Bai, Aijie Zhang, Fei Lin, Hang Tong, Tinghao Li, Ning Xu, Xinyuan Li, Zhou Yu, Hubin Yin   +9 more
wiley   +1 more source

HierAnom‐Path: Zero‐Shot Rare Cancer Detection in Histopathology via Hierarchical Foundation Model Adaptation

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Rare cancers collectively represent 20%–25% of all malignancies yet yield fewer than 50 annotated whole‐slide images (WSIs) per subtype in publicly available archives, rendering supervised deep learning inapplicable. We present HierAnom‐Path, to the best of our knowledge, the first framework for zero‐shot rare cancer anomaly detection in ...
Noora Saleem Jumaah, Mohanad Sameer Jabbar, Saif H. Alwaeli, Noor Ayesha, Mohamed Babiker A. Mohamed, Muhammad I. Khan   +5 more
wiley   +1 more source

Do evolutionary algorithm dynamics create complex network structures? [PDF]

, 2021
This paper presents a novel method for visualizing the dynamics of evolutionary algorithms in the form of complex networks. We discuss the analogy between individuals in populations in an arbitrary evolutionary algorithm and vertices of a complex network,
Jašek, Roman, Zelinka, Ivan, Šenkeřík, Roman, Davendra, Donald   +3 more
core   +1 more source

Vineyard age-specific cohorts display similar climate x esca relationships but suggest hidden drivers in younger vineyards

OENO One
Esca is a grapevine disease with a unique visual impact. Plants exhibit leaf necrosis with a tiger-striped pattern, sometimes dramatically apoplectic.
coralie Dewasme, Wander Azevedo, Gregory A. Gambetta   +2 more
doaj   +1 more source

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, Volume 159, Issue 9, Page 2290-2299, 1 November 2026.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source

ESCA COMPLEX IN THE DÃO WINE REGION (PORTUGAL)

, 2019
Tese de Doutoramento em Biociências, no ramo de Biologia Celular e Molecular, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de ...
openaire   +3 more sources