Results 181 to 190 of about 804,660 (312)

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning. [PDF]

Cell Rep Methods
Shlesinger D, Sadilek V, Minot M, Stamkopoulos E, Bikias T, Kuhn R, Agrafiotis A, Taft JM, Yermanos A, Reddy ST.   +9 more
europepmc   +1 more source

Escaping the Scaling Relationships in Oxygen Reduction Catalysis: Implications for PEM Fuel Cells

Advanced Materials, EarlyView.
Escaping the scaling relationships of the oxygen reduction reaction is vital for hydrogen fuel cells. This outlook examines how interfacial heterogeneity, spanning the subsurface lattice, chemisorption layer, and near‐interface solvation volume, mechanistically decouples intermediate binding energetics.
Muhammad Bilal Wazir, Lourdes F. Vega, Maryam Khaleel   +2 more
wiley   +1 more source

Escape room-based learning for HPV vaccine education in Japanese female university students: a controlled, three-group study. [PDF]

Sci Rep
Kondo K, Ishizuka K, Miyagami T, Ugajin M, Yuasa M, Saita M, Naito T.   +6 more
europepmc   +1 more source

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Predictive modeling of immune escape and antigenic grouping of SARS-CoV-2 variants. [PDF]

J Virol
Nasir A, Lee D, Avena LE, Berrueta DM, Speidel T, Wu K, Budigi Y, Carfi A, Stewart-Jones GBE, Edwards D.   +9 more
europepmc   +1 more source

Sustainable Poly(Lactic Acid)/Graphene Oxide Bioelectronic Platform for Neurotransmitters Sensing and Tunable Stimulation of Astrocytes

Advanced Materials, EarlyView.
This work introduces sustainable PLA/graphene oxide bioelectronic interfaces featuring electrodes with tunable conductivity and strong electrocatalytic performance. These platforms were used to implement a new method for tuning astrocyte Ca2+ signaling and for the efficient detection of key biomarkers.
Alessandra Scidà, Giulia Cazzador, Roberta Fabbri, Matteo Calosi, Alessandro Silvestri, Andrea Candini, Fabiola Liscio, Franco Corticelli, Aikaterini Konstantoulaki, Andrea D'Iorio, Marco Caprini, Vincenzo Palermo, Monica Bertoldo, Valentina Benfenati, Chiara Zanardi, Emanuele Treossi   +15 more
wiley   +1 more source

Identification of key amino acids defining conformational neutralizing epitopes of coxsackievirus A5 using monoclonal antibody escape mutants. [PDF]

Front Immunol
Xu K, Pei J, Wang C, Guo J, Chen XQ, Shen S.   +5 more
europepmc   +1 more source

Atomic‐Scale Detection of Néel Vector Switching in the Single‐Layer A‐Type Antiferromagnet Cr2S3‐2D

Advanced Materials, EarlyView.
Interfacial electron donation from graphene redistributes charge within single‐layer Cr2S3‐2D, preferentially accumulating at the lower Cr/S plane. The resulting minute magnetic imbalance lifts the equivalence of the two magnetic sublayers, enabling atomic‐resolution identification and field‐induced control of Néel‐vector states in a two‐dimensional A ...
Affan Safeer, Calisa Dias, Mahdi Ghorbani‐Asl, Abdallah Karaka, Pradyumna Bawankule, Weibin Li, Pierluigi Gargiani, Wouter Jolie, Arkady V. Krasheninnikov, Amilcar Bedoya‐Pinto, Thomas Michely, Jeison Fischer   +11 more
wiley   +1 more source

Social loneliness and internet gaming addiction among adolescents: the mediating roles of escape motivation and self-control. [PDF]

Front Psychol
Gan Q, Wang H.
europepmc   +1 more source