Results 91 to 100 of about 37,998 (252)

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

A study of Mandelbrot and Julia Sets via Picard-Thakur iteration with s-convexity.

PLoS ONE
Nowadays, many researchers are employing various iterative techniques to analyse the dynamics of fractal patterns. In this paper, we explore the formation of Mandelbrot and Julia sets using the Picard-Thakur iteration process, extended with s-convexity ...
Bashir Nawaz, Krzysztof Gdawiec, Kifayat Ullah, Maggie Aphane   +3 more
doaj   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Bioinspired Hierarchically Interconnected Supermacroporous Hydrogels via Dual‐Templating for Rapid Atmospheric Water Harvesting

Advanced Functional Materials, EarlyView.
Inspired by lung alveolar architecture, a dual‐templating strategy combining CO2 bubble and ice templating creates mechanically robust super‐macroporous hydrogels with highly interconnected transport pathways. The resulting material achieves 3.37× faster moisture sorption and 1.72× higher solar‐driven water release than single‐templated counterparts ...
Pan Huang, Weiyan Zhu, Yuanyuan Wang, Hanxiao Zhang, Ying Hu, Siyuan Yang, Wenshuai Yang, Hongbo Zeng   +7 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Cost of escape from the protective and the non-protective HLA alleles. [PDF]

, 2012
(Top row) Effect of mutations on binding affinity to 10 most protective HLA molecules according to two alternative epitope definitions (absolute criterion: , relative criterion: ).
Ilka Hoof (58673), Trevor Hinkley (82390), Can Keşmir (34541), Roger D. Kouyos (161982), Mojgan Haddad (161990), Christos J. Petropoulos (148538), Rafal Mostowy (141881), Sebastian Bonhoeffer (20372), Jeannette M. Whitcomb (161996)   +8 more
core   +1 more source

Different contractility modes control cell escape from multicellular spheroids and tumor explants

APL Bioengineering
Cells can adapt their active contractile properties to switch between dynamical migratory states and static homeostasis. Collective tissue surface tension, generated among others by the cortical contractility of single cells, can keep cell clusters ...
Eliane Blauth, Steffen Grosser, Frank Sauer, Mario Merkel, Hans Kubitschke, Enrico Warmt, Erik W. Morawetz, Philip Friedrich, Benjamin Wolf, Susanne Briest, Grit Gesine Ruth Hiller, Lars-Christian Horn, Bahriye Aktas, Josef A. Käs   +13 more
doaj   +1 more source

A Visual and Quantitative Study of Fractal Mandelbrot Sets Using the IA-Iterative Algorithm for Complex Functions

Fractal and Fractional
This paper presents a visual and quantitative study of Mandelbrot sets generated by the IA-iterative algorithm for the transcendental complex map Tc(z)=zp+sinh(cq), where p≥2, q≥1, and c∈C∖{0}.
Asifa Tassaddiq, Muhammad Tanveer, Azza M. Alghamdi, Rabab Alharbi, Aiman Albarakati, Ruhaila Md Kasmani, Dalal Khalid Almutairi   +6 more
doaj   +1 more source

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

The Nonlinear Audit Closure Principle: A Universal No-Escape Criterion for Critical Mathematical Systems

This work introduces the Nonlinear Audit Closure Principle, a universal structural criterion for assessing unconditional regularity and no-escape behavior in nonlinear systems. Rather than proposing explicit solutions or exhaustive computations, the principle formulates a necessary and sufficient audit framework based on three irreducible cuts: (i ...
openaire   +2 more sources