Results 131 to 140 of about 15,562 (220)

Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity

open access: yesAngewandte Chemie International Edition, EarlyView.
A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt   +14 more
wiley   +1 more source

Prevalence of Cystic Fibrosis Carrier Status in Chronic Rhinosinusitis Without Nasal Polyp

open access: yes
International Forum of Allergy &Rhinology, EarlyView.
Do‐Yeon Cho   +4 more
wiley   +1 more source

Modular Synthesis of Dendritic Oligo‐Glycerol Cationic Surfactants for Enhanced Antibacterial Efficacy

open access: yesAngewandte Chemie International Edition, EarlyView.
An orthogonal click chemistry approach was used to synthesize a series of cationic surfactants. The results show that an optimal balance between positive charges and hydrophobicity is a crucial factor for the improvement of antibacterial properties.
Natalie Hanheiser   +8 more
wiley   +1 more source

The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages

open access: yesCell Biochemistry and Function, Volume 40, Issue 8, Page 914-925, December 2022., 2022
Abstract ATP8B1 is a phospholipid flippase and member of the type 4 subfamily of P‐type ATPases (P4‐ATPase) subfamily. P4‐ATPases catalyze the translocation of phospholipids across biological membranes, ensuring proper membrane asymmetry, which is crucial for membrane protein targeting and activity, vesicle biogenesis, and barrier function.
Valentina E. Gómez‐Mellado   +7 more
wiley   +1 more source

Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation

open access: yesAngewandte Chemie International Edition, Accepted Article.
Pseudomonas syringae is a soil‐dwelling bacterium that exhibits remarkable niche adaptability and it is known for its devastating impact as a plant pathogen. This bacterium has an outstanding capability to produce a wide array of biologically active natural products. P.
Shuaibing Zhang   +7 more
wiley   +1 more source

Synthesis, Photophysical Properties and Biological Evaluation of New Conjugates BODIPY: Dinuclear Trithiolato‐Bridged Ruthenium(II)‐Arene Complexes

open access: yesChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Fifteen new dinuclear arene‐ruthenium (II)‐BODIPY conjugates were synthesized. Despite a fluorescence quenching effect, these conjugates can be used as fluorescent tracers. Their antiparasitic activity but also their toxicity against healthy human foreskin fibroblasts (HFFs) was reduced compared to the parent ruthenium compounds.
Oksana Desiatkina   +6 more
wiley   +1 more source

Bioinspired Cationic Antimicrobial Polymers

open access: yesAngewandte Chemie International Edition, Accepted Article.
Antibiotics are an essential tool of modern medicine, which is critically endangered by the spread of antimicrobial resistance (AMR). Without effective antibiotics, a number of medical advancements from the last century are in jeopardy, threatening our global public health and leading to a high death toll.
Heliya Javadi   +2 more
wiley   +1 more source

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