Results 231 to 240 of about 482,887 (312)

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Vaccination of Cows with a Combined Rotavirus/Enterotoxigenic "E. Coli" K99 Vaccine to Protect Newborn Calves Against Diarrhoea [PDF]

, 1983
Bachmann, P. A., Baljer, G., Eichhorn, Werner, Plank, P., Schneider, P.   +4 more
core   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, EarlyView.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

A Tripartite Fusion, FaeG-FedF-LT₁₉₂A2:B, of Enterotoxigenic Escherichia coli (ETEC) Elicits Antibodies That Neutralize Cholera Toxin, Inhibit Adherence of K88 (F4) and F18 Fimbriae, and Protect Pigs against K88ac/Heat-Labile Toxin Infection

, 2011
Xiaosai Ruan, Mei Liu, Thomas A. Casey, Weiping Zhang   +3 more
openalex   +1 more source

The CtrCBL1/CtrCIPK6 Complex of Citrus Phosphorylates CtrBBX32 to Regulate CtrSTP1‐Mediated Sugar Accumulation and Cold Tolerance

Advanced Science, EarlyView.
The CtrCBL1‐CtrCIPK6 module of trifoliate orange (Citrus trifoliata L.) phosphorylates CtrBBX32, triggering its protein degradation under cold conditions, thereby relieving CtrBBX32‐mediated transcriptional repression of CtrZAT10 and CtrSTP1. The consequent upregulation of CtrZAT10 further activates CtrSTP1 expression, which enhances hexose transport ...
Xiangming Shang, Zeqi Zhao, Wei Xiao, Yike Zeng, Mengdi Li, Xin Jiang, Bachar Dahro, Lele Chu, Min Wang, Chunlong Li, Ji‐Hong Liu   +10 more
wiley   +1 more source

Antimicrobial Drug-Resistant Shiga Toxin-Producing Escherichia coli Infections, Michigan, USA. [PDF]

Emerg Infect Dis, 2017
Mukherjee S, Mosci RE, Anderson CM, Snyder BA, Collins J, Rudrik JT, Manning SD.   +6 more
europepmc   +1 more source

Risk factors for and mortality of extended-spectrum-β-lactamase-producing Klebsiella pneumoniae and Escherichia coli nosocomial bloodstream infections [PDF]

, 2009
Silvana Vargas Superti, Gustavo Rossini Augusti, Alexandre Prehn Zavascki   +2 more
openalex   +1 more source

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

Advanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring, Brian P. Conlon, Edward A. Miao, Blossom Damania, Anna Mae Diehl, Pengda Liu   +14 more
wiley   +1 more source

<p>Risk Factors of Extended-Spectrum Beta-Lactamases-Producing <em>Escherichia coli</em> Community Acquired Urinary Tract Infections: A Systematic Review</p>

, 2020
Stéphanie Larramendy, Valentine Deglaire, Paul Dusollier, Jean‐Pascal Fournier, J. Caillon, François Beaudeau, L. Moret   +6 more
openalex   +2 more sources