Results 41 to 50 of about 491,044 (305)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Extended-Spectrum β-Lactamase (ESBL) Genotypes among Multidrug-Resistant Uropathogenic Escherichia coli Clinical Isolates from a Teaching Hospital of Nepal

Interdisciplinary Perspectives on Infectious Diseases, 2020
Urinary tract infections (UTI) represent the most common bacterial infections among patients visiting outpatient clinics of healthcare centers in Nepal.
Roshan Pandit, Balkrishna Awal, Sumesh Shreekhanda Shrestha, Govardhan Joshi, Basista Prasad Rijal, Narayan Prasad Parajuli   +5 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

FdeC, a Novel Broadly Conserved Escherichia coli Adhesin Eliciting Protection against Urinary Tract Infections

mBio, 2012
The increasing antibiotic resistance of pathogenic Escherichia coli species and the absence of a pan-protective vaccine pose major health concerns. We recently identified, by subtractive reverse vaccinology, nine Escherichia coli antigens that protect ...
Barbara Nesta, Glen Spraggon, Christopher Alteri, Danilo Gomes Moriel, Roberto Rosini, Daniele Veggi, Sara Smith, Isabella Bertoldi, Ilaria Pastorello, Ilaria Ferlenghi, Maria Rita Fontana, Gad Frankel, Harry L. T. Mobley, Rino Rappuoli, Mariagrazia Pizza, Laura Serino, Marco Soriani   +16 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Antibiotic-resistant Escherichia Coli from Retail Poultry Meat with Different Antibiotic Use Claims [PDF]

, 2018
Background We sought to determine if the prevalence of antibiotic-resistant Escherichia coli differed across retail poultry products and among major production categories, including organic, “raised without antibiotics”, and conventional.
Davis, Gregg S., Grande, Heidi, Horwinski, Joseph, Hungate, Bruce A., Koch, Benjamin, Liu, Cindy M., Nordstrom, Lora, Papp, Katerina, Price, Lance B., Waits, Kara, Weaver, Brett   +10 more
core   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Characterization of Virulence Factors and Two-Component Regulatory System Genes in Uropathogenic Escherichia coli Isolates from Young Women with Urinary Tract Infections

مجلة كلية الطب
Background: Urinary tract infections are one of the most common bacterial infections, caused mainly by Escherichia coli. Uropathogenic Escherichia coli (UPEC) possess virulence factors that can worsen infections, partly regulated by the BarA/UvrY two ...
Ali H. Al-Daraji, May T. Flayyih
doaj   +1 more source

Detection of plasmid-mediated qnr genes among the quinolone-resistant Escherichia coli isolates in Iran

Journal of Infection in Developing Countries, 2014
Introduction: Plasmid-mediated quinolone resistance, which complicates treatment, has been increasingly identified in Escherichia coli isolates worldwide.
Farzaneh Firoozeh, Mohammad Zibaei, Younes Soleimani-Asl   +2 more
doaj   +1 more source

The Potential of Use Basil and Rosemary Essential Oils as Effective Antibacterial Agents

Molecules, 2013
The considerable therapeutical problems of persistent infections caused by multidrug-resistant bacterial strains constitute a continuing need to find effective antimicrobial agents. The aim of this study was to demonstrate the activities of basil (Ocimum
Edward Kowalczyk, Wojciech Bienias, Marta Pastuszka, Monika Łysakowska, Monika Sienkiewicz   +4 more
doaj   +1 more source