Results 161 to 170 of about 55,913 (214)

An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates. [PDF]

Protein Sci
Lyu Y, Bolstad I, Davis JH, Sauer RT, Ghanbarpour A.   +4 more
europepmc   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

HPMC-ZnO Nanorods Enhance Hydrophilicity and Contact-Killing Activity on Polypropylene Meshes and Sutures. [PDF]

Pharmaceuticals (Basel)
Jana S, Malhotra A, Mittal H, Chakraborty S, Khanuja M, Singh G, Karan R, Rozhina E, Chauhan A.   +8 more
europepmc   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Synthesis and Application of Polyvinyl Alcohol (PVA) Micropowders for Antifouling Coatings. [PDF]

Materials (Basel)
Zhang D, Wei D, Xu X, Guan Y.
europepmc   +1 more source

An ALS‐associated mutation in the C‐terminal α‐helix of TDP‐43 uncouples condensate formation and amyloid assembly

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP‐43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, including fibrils composed
Emily J. Byrd, Joel A. Crossley, Chalmers C. C. Chau, Paolo Actis, Antonio N. Calabrese   +4 more
wiley   +1 more source

Cloneable contrast across all biological length scales. [PDF]

J Struct Biol
Borgognoni KM, Guilliams BF, Butz ZJ, Ackerson CJ.   +3 more
europepmc   +1 more source

Aptamer‐Functionalized Nanocarriers for Bone and Joint Diseases: Engineering Design Rules and Translational Roadmap

Small Science, Volume 6, Issue 5, May 2026.
Aptamer‐functionalized nanocarriers represent a versatile platform for targeted therapy in bone and joint diseases. This review presents five complementary design strategies: free aptamers for soluble targets, bispecific multivalent constructs for enhanced avidity, nanoparticle‐conjugated aptamers for selective tissue accumulation, aptamer‐based ...
Hamdi Al‐Azzani, Djandan Tadum Arthur Vithran, Syeda Sundas Batool, Malek Mohammed Ali Alshabi, Wenhu Zhou, Xiaoqiang Mao   +5 more
wiley   +1 more source

Tannins as Therapeutic Agents for Ulcerative Colitis: Mechanisms and Prospects in Regulating Gut Inflammatory-Oxidative Homeostasis. [PDF]

Molecules
Li Y, Sun C, Hao F, Wang Y, Zhu J, Ming Y, Tian M, Li L, Qian H.   +8 more
europepmc   +1 more source

Crystal structures of Escherichia coli glucokinase acetylation‐mimicking variants and insights into the impact of acetylation

Acta Crystallographica Section F, Volume 82, Issue 5, Page 160-166, May 2026.
This work reports the crystal structures of K214Q and K216Q variants of E. coli glucokinase, demonstrating a potential role of lysine acetylation in regulating glucokinase activity.In this study, we report the crystal structures of K214Q and K216Q variants of Escherichia coli glucokinase (ecGLK), each of which is bound to phosphate in the active‐site ...
Joseph Andrews, Joshua Sakon, Chenguang Fan   +2 more
wiley   +1 more source