Results 41 to 50 of about 65,470 (161)

Methodological insights and clinical outcomes in ALS and FTLD: lessons from the SPIN cohort

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) constitute a clinico‐genetic‐neuropathological continuum with marked heterogeneity. Reliable in vivo biomarkers of the disease are lacking. Large, multimodal cohorts are needed to advance biomarker discovery and precision medicine. METHODS We describe
Álvaro Carbayo, Janina Turon‐Sans, Daniel Alcolea, Elena Cortés‐Vicente, Manuel Cabezas‐Torres, Esther Alvarez‐Sanchez, Laia Muñoz, Sara Rubio‐Guerra, Jesús García‐Castro, Judit Selma‐González, Sara Bernal, Lidia Gonzalez‐Quereda, Alexandre Bejanin, Mateus Rozalem Aranha, Miguel Santos‐Santos, Olivia Belbin, Ana Vesperinas‐Castro, Roger Collet‐Vidiella, Marta Caballero‐Ávila, Laura Llansó, Luis Querol, Alberto Lleó, Juan Fortea, Ellen Gelpí, Oriol Dols‐Icardo, Ignacio Illán‐Gala, Ricard Rojas‐Garcia   +26 more
wiley   +1 more source

Informe del Estudio. Actividad Física y Deporte en Esclerosis Múltiple [PDF]

, 2016
Tradicionalmente, el ejercicio como parte del abordaje de la Esclerosis Múltiple ha sido infrautilizado y objeto de controversia. A menudo, los médicos recomendaban que se evitara realizar ejercicio físico a las personas con esta enfermedad, debido sobre
Esclerosis Múltiple España
core  

Recomendaciones para la utilización e interpretación de los estudios de resonancia magnética en la esclerosis múltiple

Neurología, 2010
Resumen: Objetivo: Establecer unas recomendaciones para utilizar e interpretar la resonancia magnética (RM) en el diagnóstico y el seguimiento de la esclerosis múltiple (EM).
A. Rovira, M. Tintoré, J.C. Álvarez-Cermeño, G. Izquierdo, J.M. Prieto   +4 more
doaj   +1 more source

Early Upper Limb Motor Impairment in Multiple Sclerosis Across EDSS Levels: A Case–Control Study

Brain and Behavior, Volume 16, Issue 8, August 2026.
Upper limb function is impaired in people with multiple sclerosis compared with healthy controls, even at low levels of neurological disability. Patients are stratified by Expanded Disability Status Scale (EDSS) score (≤3.5 and >3.5) and assessed using objective upper limb measures.
Aitor Blázquez‐Fernández, Selena Marcos‐Antón, Cecilia Estrada‐Barranco, Patricia Martín‐Casas, Rosa María Ortiz‐Gutiérrez, Carmen Jiménez‐Antona, Sofía Laguarta‐Val, Roberto Cano‐de‐la‐Cuerda   +7 more
wiley   +1 more source

How oral probiotics affect the severity of an experimental model of progressive multiple sclerosis? Bringing commensal bacteria into the neurodegenerative process

Gut Microbes, 2020
A growing number of studies support that the bidirectional interactions between the gut microbiota, the immune system and the CNS are relevant for the pathophysiology of MS.
Leyre Mestre, Francisco J. Carrillo-Salinas, Ana Feliú, Miriam Mecha, Graciela Alonso, Carmen Espejo, Laura Calvo-Barreiro, José L. Luque-García, Héctor Estevez, Luisa María Villar, Carmen Guaza   +10 more
doaj   +1 more source

Prenatal diagnosis of cardiac rhabdomyoma: implications for predicting tuberous sclerosis complex and guiding perinatal management

Ultrasound in Obstetrics &Gynecology, Volume 68, Issue 1, Page 88-98, July 2026.
ABSTRACT Objective To identify prenatal predictors of tuberous sclerosis complex (TSC) in fetuses with one or more cardiac rhabdomyomas (CR), evaluate an integrated multimodal diagnostic workflow using fetal magnetic resonance imaging (MRI) and trio whole‐exome sequencing (trio‐WES) and characterize perinatal outcomes.
X. Cai, J. Liu, W. Zheng, Y. Jiao, Y. Lou, M. Deng, W. Zhao, K. Yan, L. Sun   +8 more
wiley   +1 more source

Evaluación de la calidad de vida en Esclerosis Múltiple a través del MSQOL-54 y su relación con la salud de la persona

Enfermería Global, 2021
Objetivo: El objetivo del presente estudio fue evaluar la Calidad de Vida Relacionada con la salud (CVRS) en personas con Esclerosis Múltiple (EM) mediante el cuestionario MSQOL-54 y analizar su relación con la salud de las personas cuidadoras ...
María Dolores Martínez-Espejo, Rosa María Limiñana-Gras, Rosa María Patró-Hernández, José Eustasio Meca Lallana, Encarnación Aznar Robles, María del Carmen Márquez Rebollo   +5 more
doaj   +1 more source

Clusters of Comorbidities in Multiple Sclerosis and Their Influence on Healthcare Resource Usage

European Journal of Neurology, Volume 32, Issue 11, November 2025.
Using latent‐class models in a population‐based sample of MS patients, cardiovascular and psychiatric clusters were identified. Nurse visits and medication dispensation were higher in the cardiovascular cluster, and annual sick‐leave days were higher in the psychiatric cluster.
Simón Cárdenas‐Robledo, Susana Otero‐Romero, Juan David García, Nuria López, Pere Carbonell‐Mirabent, Marta Rodríguez, Claudia Guío‐Sánchez, René Carvajal, Maria Angels Passarell‐Bacradit, Jaume Sastre‐Garriga, Xavier Montalban, Mar Tintoré   +11 more
wiley   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, Volume 12, Issue 9, Page 1894-1900, September 2025.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

Short‐chain fatty acids in multiple sclerosis: Associated with disability, number of T2 lesions, and inflammatory profile

Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 478-490, March 2025.
Abstract Objective An alteration in the composition of the intestinal microbiota has been observed in patients with multiple sclerosis (pwMS) with respect to healthy controls (HC). Microorganism‐derived metabolites such as short‐chain fatty acids (SCFA) have been suggested to play a role in the disease.
Maria Inmaculada Dominguez‐Mozo, Daniel López‐Mecández, Luisa María Villar, Lucienne Costa‐Frossard, Noelia Villarrubia, Yolanda Aladro, Belén Pilo, Xavier Montalbán, Manuel Comabella, Ignacio Casanova‐Peño, Inés González‐Suárez, María Luisa Martínez‐Ginés, Jose Manuel García‐Domínguez, Estefanía García‐Calvo, Andrés Machuca‐Marcos, Jose Luis Luque‐Garcia, María Angel Garcia‐Martinez, Rafael Arroyo, Roberto Alvarez‐Lafuente   +18 more
wiley   +1 more source