Results 121 to 130 of about 177,462 (248)

Protective Mechanism of Aqueous Extract From Ixeris sonchifolia in Myocardial Ischemia–Reperfusion Injury: Insights From Network Pharmacology and Experimental Validation

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study evaluated KDZ aqueous extract's therapeutic potential for MI/RI and investigated its mechanism. In a mouse MI/RI model, the aqueous extract mitigated injury and preserved cardiac function. Liquid chromatography‐mass spectrometry (LC–MS) identified eighty‐six components. Based on Compound‐target‐disease interaction network and KEGG enrichment
Xiaoxia Tian, Baoyi Chen, Longtai Chen, Kuan Liu, Jiazhao Chu, Fang Liu, Sijing Feng, Lina Lai   +7 more
wiley   +1 more source

Structural characterization of 132-hydroxy-(132-S)-phaeophytin-a from leaves and stems of Amaranthus tricolor isolated by high-speed countercurrent chromatography

, 2007
G. Jerz, T. Arrey, V. Wray, Q. Du, P. Winterhalter   +4 more
semanticscholar   +1 more source

Challenges and Opportunities for National‐Scale Projections of Future Coastal Landscape Change

Earth's Future, Volume 14, Issue 4, April 2026.
Abstract Local to global scale projections of future coastal landscape change are essential to improve land and resource management decisions that aim to prepare for and reduce risk exposure to impending coastal hazards. However, the availability of actionable knowledge is often limited due to the complexity of drivers of change, their consequences ...
Erika E. Lentz, Davina L. Passeri, Sara L. Zeigler, Kate White, Thomas Wahl, Amanda D. Stoltz, Elizabeth A. Pendleton, Shubhra Misra, Trevor Meckley, Ben Hamlington, Neil Ganju, Amanda E. Cravens, Joel Carr, Christine A. Buckel   +13 more
wiley   +1 more source

Drivers of Benthic Iron Fluxes and the Pore‐Water Iron Isotopic Signature in Surface Sediments of South Georgia Fjords, Sub‐Antarctica

Global Biogeochemical Cycles, Volume 40, Issue 4, April 2026.
Abstract Benthic iron (Fe) fluxes from coastal sediments support phytoplankton blooms downstream of subpolar islands. We combine solid‐phase and pore‐water geochemical data, including its iron isotopic signature (δ56Feaq), to identify the main drivers of benthic Fe fluxes from sub‐Antarctic fjord and shelf sediments of South Georgia, and to evaluate ...
Berenice Ebner, Susann Henkel, Peter Kraal, Daniel Müller, Male Köster, Michael Staubwasser, Katja Laufer‐Meiser, Laura Kattein, Walter Geibert, Sabine Kasten   +9 more
wiley   +1 more source

Pck1 Deficiency Drives Mitochondrial Dysfunction and Cellular Senescence in Adipocytes

Aging Cell, Volume 25, Issue 4, April 2026.
Phosphoenolpyruvate carboxykinase 1 (Pck1) expression is downregulated in aging white adipose tissue. Adipocyte Pck1 deficiency impairs TCA cycle cataplerosis, causing fumarate accumulation. Excess fumarate disrupts mitochondrial homeostasis, triggers oxidative stress and mtDNA release, activating cGAS–STING signaling and driving inflammaging ...
Yiting Lei, Meng Yang, Xiaoyun Jiang, Yujie Zhang, Yuzhi Chen, Weiheng Xie, Qihui Dai, Weihong Qin, Xiuqin Deng, Xiaojun Zhang, Zhongjun Zhou, Gonghua Huang, Xinguang Liu   +12 more
wiley   +1 more source

Sex‐specific impact of repeated adolescent vapour exposure to JWH‐018 on dopamine response, behaviour and pharmacokinetics across adolescence and adulthood

British Journal of Pharmacology, Volume 183, Issue 7, Page 1517-1538, April 2026.
Abstract Background and Purpose Alarming trends show that vaping e‐cigarettes containing synthetic cannabinoid receptor agonists, such as JWH‐018, is increasing among youth. However, the effects of these trends are unclear in both sexes. We therefore characterized the neuropharmacological effects of adolescent JWH‐018 inhalation in male and female rats.
Nicholas Pintori, Cristina Manis, Enrica Spano, Nicola Simola, Alessandro Ieraci, Pierluigi Caboni, Gaetano Di Chiara, Maria Antonietta De Luca   +7 more
wiley   +1 more source

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum

Plant Biotechnology Journal, Volume 24, Issue 4, Page 1936-1949, April 2026.
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
wiley   +1 more source

Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2541-2558, April 2026.
ABSTRACT Hyaluronic acid (HA) is a glycosaminoglycan composed of alternating units of N‐acetylglucosamine and glucuronic acid. High moisture retention, viscoelasticity and biocompatibility are unique features that make HA polymers attractive compounds for medical applications and aesthetic purposes.
Amanda Lopes, Omar Sandoval‐Ibáñez, Stéphanie Arrivault, David Rolo, F. Vanessa Loiacono, Alexander Erban, Daniel Karcher, Stephan Obst, Stephanie Ruf, Joachim Kopka, Ralph Bock   +10 more
wiley   +1 more source

Annual Patient EXposure of residents in training over 20 years (APEX-trial): a retrospective analysis from a public teaching hospital. [PDF]

BMJ Open
Sturm Kunz C, Gerhards V, Ballmer FH, Gantenbein A, Schwendinger M, Beer JH, Wertli MM.   +6 more
europepmc   +1 more source

Large‐scale chromatin remodeling in germinal vesicle bovine oocytes: Interplay with gap junction functionality and developmental competence

Molecular Reproduction and Development, 2007
V. Lodde, S. Modina, C. Galbusera, F. Franciosi, A. M. Luciano   +4 more
semanticscholar   +1 more source