Potential peptidic proteasome inhibitors by incorporation of an electrophilic trap based on amino acid derived α-substituted sulfonyl fluorides [PDF]
, 2017 Peptido sulfonyl fluoride derivatives were designed and synthesized containing a substituent on the alpha position (αPSFs) with respect to the sulfonyl fluoride electrophilic trap.
Brouwer, Arwin J. +3 more
core +1 more source
Bulletin of the Seismological Society of America, 2010 The Wenchuan earthquake of 12 May 2008 in Sichuan Province, China, can be classified as a large-scale event based on the tectonic structures that triggered the earthquake and the effects caused on the human, structural, and natural environment. This paper presents the geotectonic and seismotectonic regime of the earthquake-affected region on the basis
openaire +2 more sources
Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model
Integrative Zoology, EarlyView.UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang +5 more
wiley +1 more source
Cold gas and a Milky Way-type 2175 {\AA} bump in a metal-rich and highly depleted absorption system
, 2015 We report the detection of a strong Milky Way-type 2175 \AA$ $ extinction bump at $z$ = 2.1166 in the quasar spectrum towards SDSS J121143.42+083349.7 from the Sloan Digital Sky Survey (SDSS) Data Release 10.
Caucal, Paul +11 more
core +3 more sources
De Stupro: First Insights on Rape and Its Prosecution in Maltese Courts (1701–10)
Journal for Eighteenth-Century Studies, EarlyView.Abstract This article constitutes a first in‐depth investigation of rape and the prosecution of this crime in early eighteenth‐century Malta. The research, which is based on sixteen rape accusations claimed at the secular courts in Malta between 1701 and 1710, has analysed cases categorized as ‘simple rape’, ‘violent rape’ and rape committed under the ...
Vanessa Buhagiar
wiley +1 more source
The Provenance of Silver in the Viking‐Age Hoard From Bedale, North Yorkshire
Archaeometry, EarlyView.ABSTRACT The acquisition of silver was a key motive propelling the Viking expansion out of Scandinavia; identifying the sources of Viking silver during the early part of the Viking Age can provide critical insights into the relative significance of western European and eastern, Islamic wealth in the Viking expansion.
Jane Kershaw +5 more
wiley +1 more source
A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto +12 more
wiley +1 more source
Illness Severity among Non-English, Non-Spanish Speaking Patients in a Public Emergency Department [PDF]
, 2017 Background: Patients with limited English proficiency (LEP) have poor health outcomes compared to English proficient patients. Most studies on language proficiency and health disparities focus on Spanish.
Dirvonas, Tyler, M.D. +4 more
core +1 more source
Element Abundances in a Gas-rich Galaxy at z = 5: Clues to the Early Chemical Enrichment of Galaxies
, 2016 Element abundances in high-redshift quasar absorbers offer excellent probes of the chemical enrichment of distant galaxies, and can constrain models for population III and early population II stars.
DeMarcy, Bryan +5 more
core +3 more sources
Microwave-mediated synthesis of N-methyliminodiacetic acid (MIDA) boronates [PDF]
, 2014 A library of over 20, mainly aryl or heteroaryl, N-methyliminodiacetic acid (MIDA) boronates have been synthesised. A rapid microwave-mediated (MW) method (5–10 min) has been developed using polyethylene glycol 300 (PEG 300) as solvent.
Close, Adam J +3 more
core +1 more source