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NICE reconsiders esketamine for depression

BMJ, 2020
The National Institute for Health and Care Excellence (NICE) has launched a second consultation on the use of esketamine for treatment resistant depression, after feedback showed that it could benefit some patients. Guidance published in January 2020 did not recommend esketamine for treatment resistant depression and said that the drug should not be ...
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Esketamine for treatment-resistant depression

Drug and Therapeutics Bulletin, 2020
Generic name: Esketamine hydrochloride Brand name: Spravato Formulation: 28mg in 0.2ml nasal spray solution Market Authorisation holder: Janssen-Cilag International NV Indication: Treatment resistant
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Esketamine: Less Drowsiness, More Analgesia

Anesthesia & Analgesia
Racemic ketamine is a 1:1 mixture of 2 enantiomers that turn light in opposite direction: Dextrorotatory esketamine is approximately 4 times more affine for the N-methyl-D-aspartate (NMDA) receptor than levorotatory arketamine, which may explain why esketamine is about twice as potent as an analgesic and anesthetic as the racemate.
Georges, Mion, Sabine, Himmelseher
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Ketamin und Esketamin

Nervenheilkunde
ZUSAMMENFASSUNGKetamin blickt bereits auf eine längere Geschichte der Anwendung in der Psychiatrie zurück. Insbesondere ist es in den letzten 2 Dekaden zur Behandlung von therapieresistenten Depressionen erforscht und eingesetzt worden und ist mit dem Enantiomer Esketamin in Deutschland für diese Indikation zugelassen.
Cornelius Schüle   +2 more
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Esketamine for Postpartum Suicidality

Biological Psychiatry, 2021
Catarina, Machado   +3 more
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Esketamine

Reactions Weekly, 2019
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