Results 41 to 50 of about 3,196,781 (312)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A novel device to assess the oxygen saturation and congestion status of the gastric conduit in thoracic esophagectomy

BMC Surgery
Background In thoracic esophagectomy, anastomotic leakage is one of the most important surgical complications. Indocyanine green (ICG) is the most widely used method to assess tissue blood flow; however, this technique has been pointed out to have ...
Takeo Fujita, Takashi Shigeno, Daisuke Kajiyama, Kazuma Sato, Naoto Fujiwara, Hiroyuki Daiko   +5 more
doaj   +1 more source

Esophageal Squamous Cell Cancer: Pathogenesis and Epidemiology

, 2019
Esophageal cancer is a highly lethal disease. Despite the rapidly increasing incidence of adenocarcinoma in last decades, squamous cell carcinoma remains the predominant cell type worldwide.
Tong, KHD, Law, SYK
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Overview of esophageal cancer [PDF]

Annals of Cardiothoracic Surgery, 2017
Esophageal cancer is a male-dominant aggressive malignancy and a leading cause of cancer-related mortality worldwide. Squamous cell carcinoma and adenocarcinoma are the two predominant histological subtypes with varying geographical and racial distribution. Globally, squamous cell carcinoma remains the most common histological type.
Ghulam, Abbas, Mark, Krasna
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Comprehensive analysis based on the ubiquitination- and deubiquitylation-related genes reveals the function of NEURL3 in esophageal squamous cell carcinoma

Frontiers in Immunology
BackgroundAs a highly invasive gastrointestinal malignancy, esophageal squamous cell carcinoma (ESCC) carries with its high morbidity and mortality. Accumulating evidence indicates that abnormal activation of ubiquitination and deubiquitylation has been ...
Yi-Wei Lin, Yi-Wei Lin, Hui-Er Li, Hui-Er Li, Chao-Qun Hong, Zi-Ang Chen, Zi-Ang Chen, Shu-Ping Liu, Shu-Ping Liu, Yi-Wei Xu, Yi-Wei Xu, Fang-Cai Wu, Yu-Hui Peng, Yu-Hui Peng   +13 more
doaj   +1 more source

A revamped MIC-McKeown operation without removing azygos vein arch, bronchial artery and vagus nerve trunk

BMC Surgery, 2023
Background The purpose of this study was to investigate the effect of our revamped MIE-McKeown operation on postoperative gastrointestinal function recovery.
Hai Zhang, Ying Chen, Bomeng Wu, Ying Chen, Haiquan He, Lanjuan Gong, Linrong Zhou, Cui Li, Jing Xie, Wanli Lin   +9 more
doaj   +1 more source

miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression

, 2014
[[abstract]]Esophageal cancer is an aggressive human malignancy with rising incidence in the developed world. The vascular endothelial growth factor VEGF-C makes crucial contributions to esophageal cancer progression that are not well understood. Here we
Hong, CC;Chen, PS;Chiou, J;Chiu, CF;Yang, CY;Hsiao, M;Chang, YW;Yu, YH;Hung, MC;Hsu, NW;Shiah, SG;Hsu, NY;Su, JL
core   +1 more source