Results 71 to 80 of about 3,196,781 (312)
Advanced Science, EarlyView.In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang +6 more
wiley +1 more source
Serglycin promotes migration and invasion of esophageal cancer cells
, 2018 Esophageal cancer is the eighth most common cancer in the world and it ranks sixth in mortality rate among cancer diseases. While patients with early stage esophageal cancer without metastasis have a better chance of being cured by surgery, most patients
Lam, Aky +10 more
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Defining a positive circumferential resection margin in oesophageal cancer and its implications for adjuvant treatment [PDF]
, 2013 A positive circumferential resection margin (CRM) has been associated with a poorer prognosis in oesophageal and oesophagogastric junctional (OGJ) cancer. The College of American Pathologists defines the CRM as positive if tumour cells are present at the
Driscoll, P J +6 more
core +1 more source
Endoscopic Management of Esophageal Cancer
, 2022 SIMPLE SUMMARY: Esophageal cancer is a leading cause of cancer-related mortality worldwide. With ongoing innovation in endoscopy and improved understanding of this disease, minimally-invasive endoluminal procedures have served a growing role in diagnosis,
Alireza Sedarat +3 more
core +1 more source
Advanced Science, EarlyView.A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen +14 more
wiley +1 more source
T2N0M0 esophageal cancer [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2007 The study objective was to develop a treatment algorithm for cT2N0M0 esophageal cancer by determining (1) errors in clinical staging and (2) consequences of overtreatment and undertreatment of incorrectly clinically staged patients.Of 742 clinically staged patients, 61 (8.2%) had cT2N0M0 cancer; 45 underwent surgery alone; 8 underwent surgery and ...
Rice, Thomas W. +6 more
openaire +2 more sources
Advanced Science, EarlyView.This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng +13 more
wiley +1 more source
Analysis of the Relationships between Esophageal Cancer Cases and Climatic Factors Using a Geographic Information System (GIS): a Case Study of Ardabil province in Iran [PDF]
Esophageal cancer is a mjaor health problems in many parts of the world. A geographical information system (GIS) allows investigation of the geographical distribution of diseases. The purpose of the present study was to explore the relationship between
صادقیه اهری, سعید +4 more
core
Therapeutic Strategies Against Cancer Stem Cells in Esophageal Carcinomas.
, 2020 Cancer stem cells (CSCs) in esophageal cancer have a key role in tumor initiation, progression and therapy resistance. Novel therapeutic strategies to target CSCs are being tested, however, more in-depth research is necessary.
Smith, Robert A +3 more
core +1 more source
Advanced Science, EarlyView.Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang +9 more
wiley +1 more source