Results 91 to 100 of about 177,438 (306)

Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis. [PDF]

, 2014
Barretts esophagus (BE) involves a metaplastic replacement of native esophageal squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor for Barrett-related adenocarcinoma (BAc).
Baffa, R, Bornschein, J, Braconi, C, Croce, CM, D'Angelo, E, Dall'Olmo, L, Fassan, M, Galasso, M, Gasparini, P, Nuovo, GJ, Pizzi, M, Realdon, S, Rugge, M, Souza, RF, Valeri, N, Vicentini, C, Volinia, S, Zaninotto, G   +17 more
core   +4 more sources

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Increasing Rates of Esophageal Stricture and Dilation Over 2 Decades in Eosinophilic Esophagitis

Gastro Hep Advances, 2023
S.B. Greenberg, A.A. Ocampo, Z. Xue, N.C. Chang, K.P. Thakkar, S.B. Reddy, C.J. Lee, C.J. Ketchem, W.D. Redd, S. Eluri, C.C. Reed, E.S. Dellon   +11 more
doaj   +1 more source

KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.

PLoS ONE, 2019
Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among the leading causes of morbidity and mortality throughout the world.
Khvaramze Shaverdashvili, Jennie Padlo, Daniel Weinblatt, Yang Jia, Wenpeng Jiang, Divya Rao, Dorottya Laczkó, Kelly A Whelan, John P Lynch, Amanda B Muir, Jonathan P Katz   +10 more
doaj   +1 more source

Esophageal reconstruction results in surgery of pediatric patients with complex esophageal pathology in two high level hospitals of Medellín, Colombia, 2006-2016

Iatreia, 2017
Introduction: complex esophagus represents a final condition that occurs secondary to diseases that require multiple procedures or esophageal replacement surgery, either because it is the only treatment or because others interventions have failed.
Herrera-Toro, Natalia, Arango-Rave, María Elena, Peña-Aguirre, Laura, Silvera-Valera, Michelle Carolina   +3 more
doaj   +1 more source

AIDS-defining illnesses at initial diagnosis of HIV in a large Guatemalan cohort [PDF]

, 2017
BackgroundAnecdotal evidence suggests that a high proportion of patients diagnosed with HIV in Guatemala present with AIDS. There remain limited data on the epidemiology of AIDS-defining illnesses (ADIs) in Central America.MethodsWe conducted a ...
Cordon, Andrea Alonzo, Melendez, Johanna, Powderly, William G, Reinhardt, Samuel W, Ross, Ian, Spec, Andrej, Villatoro, Carlos Mejia   +6 more
core   +2 more sources

Esophageal Crohn’s disease [PDF]

Endoscopy, 2009
G-C, Lou, J-M, Yang, W, Huang, J, Zhang, B, Zhou   +4 more
openaire   +2 more sources

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Endoscopic therapy for Barrett′s esophagus

Journal of Digestive Endoscopy, 2012
Barrett’s esophagus (BE) is the precursor lesion to esophageal adenocarcinoma. This cancer has undergone a rapid increase in incidence in Western societies in the last 30 years.
Nicholas J. Shaheen
doaj   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source