Results 211 to 220 of about 176,987 (331)

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, EarlyView.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Causal effects of genetically determined metabolites and metabolite ratios on esophageal diseases: a two-sample Mendelian randomization study. [PDF]

BMC Gastroenterol
Yang H, Wang Y, Zhao Y, Cao L, Chen C, Yu W.   +5 more
europepmc   +1 more source

Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. [PDF]

Nat Commun, 2019
An J, Gharahkhani P, Law MH, Ong JS, Han X, Olsen CM, Neale RE, Lai J, Vaughan TL, Gockel I, Thieme R, Böhmer AC, Jankowski J, Fitzgerald RC, Schumacher J, Palles C, BEACON, 23andMe Research Team, Whiteman DC, MacGregor S.   +19 more
europepmc   +1 more source

Esophageal body function in patients with paraesophageal hernia is similar to those with gastroesophageal reflux disease

, 2000
Stephen Archer, C. Daniel Smith, Gene D. Branum, Kathy Galloway, Patrick J. Waring, John G. Hunter   +5 more
openalex   +1 more source

Functional models from limited data: A parametric and multimodal approach to anatomy and 3D kinematics of feeding in basking sharks (Cetorhinus maximus)

The Anatomical Record, EarlyView.
Abstract Basking sharks, Cetorhinus maximus (Gunnerus, Brugden [Squalus maximus], Det Kongelige Norske Videnskabers Selskabs Skrifter, 1765, vol. 3, pp. 33–49), feed by gaping their mouths and gill slits, greatly reorienting their cranial skeletons to filter food from water.
Tairan Li, Mike Schindler, Martha Paskin, Venkata A. Surapaneni, Elliott Scott, Sabine Hauert, Nicholas Payne, David E. Cade, Jeremy A. Goldbogen, Frederik H. Mollen, Daniel Baum, Sean Hanna, Mason N. Dean   +12 more
wiley   +1 more source

Eosinophilic esophagitis and celiac disease [PDF]

Minerva Gastroenterologica e Dietologica, 2018
openaire   +3 more sources

A contribution to the anatomy of two rare cetacean species: The hourglass dolphin (Cephalorhynchus cruciger) and the spectacled porpoise (Phocoena dioptrica)

The Anatomical Record, EarlyView.
Abstract The anatomical description of the hourglass dolphin (Cephalorhynchus cruciger) and the spectacled porpoise (Phocoena dioptrica) remains largely unexplored, due to limited specimen availability and preservation challenges. This study employed digital imaging techniques, conventional histology, and computed tomography to provide visualization of
Jean‐Marie Graïc, Tommaso Gerussi, Bruno Cozzi, Rebecca M. Boys, Brian Chin Wing Kot, Matthew R. Perrott, Kane Fleury, Tabris Yik To Chung, Henry Chun Lok Tsui, Emma Burns, Trudi Webster, Stuart Hunter, Emma L. Betty, Odette Howarth, Carolina Loch, Sophie White, Steve Dawson, William Rayment, Ros Cole, Derek Cox, Tom Waterhouse, Hannah Hendriks, Anton van Helden, Muriel Johnstone, Ramari Oliphant Stewart, R. Ewan Fordyce, Karen A. Stockin   +26 more
wiley   +1 more source

Causal effects of genetic birth weight and gestational age on adult esophageal diseases: Mendelian randomization study. [PDF]

World J Gastrointest Oncol
Ruan LC, Zhang Y, Su L, Zhu LX, Wang SL, Guo Q, Wan BG, Qiu SY, Hu S, Wei YP, Zheng QL.   +10 more
europepmc   +1 more source

Author Correction: Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. [PDF]

Nat Commun, 2019
An J, Gharahkhani P, Law MH, Ong JS, Han X, Olsen CM, Neale RE, Lai J, Vaughan TL, Gockel I, Thieme R, Böhmer AC, Jankowski J, Fitzgerald RC, Schumacher J, Palles C, BEACON, 23andMe Research Team, Whiteman DC, MacGregor S.   +19 more
europepmc   +1 more source

24-Hour monitoring of acid clearance in patients with gastroesophageal reflux disease: Assessed by ambulatory esophageal manometry and pH-metry

, 2000
Junichi Akiyama, Kei Matsueda, Shoda Ryosuke, Shigeru Yamato, Akira Muraoka, Masako Asayama, Hideya Yoshinaga, Hiroyuki Oka, Hitoshi Baba, Hiroko Yamashita, Naohiko Masaki, Shigeki Hayashi   +11 more
openalex   +1 more source