Results 71 to 80 of about 1,110,911 (288)
CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells
Advanced Science, EarlyView.AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu +6 more
wiley +1 more source
Introduction: Esophageal Adenocarcinoma: Updates of Current Status
, 2018 Esophageal and esophagogastric adenocarcinoma is highly prevalent in the Western populations and is a major cause of cancer-related morbidity and mortality worldwide. The incidence of esophageal adenocarcinoma is rapidly rising in the Western populations.
Lam, AK, Alfred K. Lam
core +1 more source
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Advanced Science, EarlyView.Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley +1 more source
Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs
Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley +1 more source
Advanced Science, EarlyView.Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi +13 more
wiley +1 more source
Treatment of Esophageal Injury
The Korean Journal of Thoracic and Cardiovascular Surgery, 2010 Background: Esophageal injury requires early and proper management. We want to determine the results of various esophageal injuries. Material and Method: We respectively analyzed 22 patients who were managed for esophageal injury between 1999 and 2009. Based on the medical records, we reviewed the causes of injury, the diagnoses, the treatment methods,
Hee Jae Sim +6 more
openaire +1 more source
Evaluation of the neo-glottal closure based on the source description in esophageal voice [PDF]
, 2008 The characteristics of esophageal voice render its study by traditional acoustic means to be limited and complicate. These limitations are even stronger when working with patients lacking minimal skills to control the required technique. Nevertheless the
Fernández-Baillo Gallego de la Sacristana, Roberto +3 more
core
Advanced Science, EarlyView.Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao +9 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Small intestinal bacterial overgrowth (SIBO) has recently gained increasing attention as a potential cause of postoperative gastrointestinal symptoms following gastrointestinal cancer surgery. Surgical procedures can disrupt normal gastrointestinal physiology through anatomical reconstruction, impaired motility, reduced gastric acid secretion,
Toru Aoyama +2 more
wiley +1 more source
Corrosive Injuries of the Upper Gastrointestinal Tract
Journal of Digestive Endoscopy, 2017 Corrosive injury of the upper gastrointestinal tract is a worldwide clinical problem, mostly occurring in children. Alkaline agents produce deeper injuries whereas acidic agents produce superficial injuries usually.
Babu Lal Meena +4 more
doaj +1 more source