Results 41 to 50 of about 664 (217)
Advanced Science, EarlyView.This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan +6 more
wiley +1 more source
PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Advanced Science, EarlyView.Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018 Aim of investigation. To study dynamics of morbidity gastrointestinal tumors in Kabardino-Balkar Republic for 25-year period, to compare to the Russian and world wide epidemiological data. Material and methods. Annual reports of oncological dispensary of
A. A. Tkhakakhov
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Solitary Esophageal Varix Simulating a Neoplasm [PDF]
Australasian Radiology, 1988 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/73070/1/j.1440-1673.1988.tb02785.x ...
openaire +3 more sources
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Esophageal stricture assessment by esophagogram: A pictorial review of differential diagnosis
Clinical and Biomedical Research, 2019 The purpose of this article is to review the most frequent conditions associated with esophageal strictures on esophagogram. The most common causes include caustic ingestion, radiation therapy, malignancy, extrinsic compression, gastroesophageal reflux ...
Marcio Aloisio Bezerra Cavalcanti Rockenbach +2 more
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CLINICAL EFFECTIVENESS OF ENDOSCOPIC SUBMUCOSAL DISSECTION IN THE MANAGEMENT OF SUPERFICIAL ESOPHAGEAL NEOPLASMS ASSOCIATED WITH BARRETT’S ESOPHAGUS [PDF]
Arquivos de GastroenterologiaBackground: The main clinical impact of superficial neoplasms associated with Barrett’s esophagus lies in their increasing oncogenic potential in the medium and long term.
Rúbia Moresi VIANNA DE OLIVEIRA +3 more
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Advanced Science, EarlyView.This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori +10 more
wiley +1 more source
Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment
Advanced Science, EarlyView.This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo +15 more
wiley +1 more source
Achalasia Combined with Esophageal Cancer Treated by Concurrent Chemoradiation Therapy
Gut and Liver, 2009 Achalasia is a rare neurological deficit of the esophagus that produces an impaired relaxation of the lower esophageal sphincter and decreased motility of the esophageal body.
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