Results 151 to 160 of about 4,384,248 (335)

Optimal PEEP with lowest (least injurious) transpulmonary driving pressure can be determined by a rapid two-PEEP-step procedure without esophageal pressure. [PDF]

Crit Care, 2022
Stenqvist O.
europepmc   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Esophageal Pressure and Clinical Assessments in the Gastroesophageal Reflux Disease Patients with Laryngopharyngeal Reflux Disease. [PDF]

J Clin Med, 2021
Tsou YA, Chen SH, Wu WC, Tsai MH, Bassa D, Shih LC, Chang WD.   +6 more
europepmc   +1 more source

Effects of intraduodenally applied bile salts on pancreatic secretion [PDF]

, 1993
Lehnert, Peter, Riepl, Rudolf L.
core   +1 more source

A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors. [PDF]

, 2015
BackgroundThis first-in-human study evaluated AMG 208, a small-molecule MET inhibitor, in patients with advanced solid tumors.MethodsThree to nine patients were enrolled into one of seven AMG 208 dose cohorts (25, 50, 100, 150, 200, 300, and 400 mg ...
Amore, Benny, Beaupre, Darrin M, Caudillo, Isaac, Deng, Hongjie, Fu, Siqing, Hong, David S, Hwang, Yuying C, Janku, Filip, Khan, Rabia, Kurzrock, Razelle, Lee, Peter, Loberg, Robert, Lockhart, A Craig, Ngarmchamnanrith, Gataree, Rosen, Peter   +14 more
core   +2 more sources

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

International Journal of Cancer, EarlyView.
What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto, Sophie Gibert, Caroline Delmas, David Tougeron, Amaury Paumier, Alexandre Taillez, Samuel Le Sourd, Delphine Argo Leignel, Philippe Ronchin, Ariane Darut Jouve, Véronique Vendrely, Olivier Riou, Jérôme Martin‐Babau, Thomas Leroy, Laurent Quéro, Naïma Hanoun, Pierre Cordelier, Veronica Pezzella, Jean Pierre Delord, Rosine Guimbaud, Elizabeth Moyal, Catherine Seva   +21 more
wiley   +1 more source

Outcomes and risk factors of hemorrhage in patients with resected brain metastases

International Journal of Cancer, EarlyView.
What's New? Brain metastases may present with hemorrhage, yet risk factors and clinical outcomes remain unclear. Based on a cohort of 880 patients with resected brain metastases, this study identified tumor volume and primary tumor histology (melanoma and non‐small cell lung cancer) as key predictors of hemorrhage.
Melisa S. Guelen, Kiarash Ferdowssian, Niklas Jung, Hava N. Celik, Andrea Dell'Orco, Semil Eminovic, Anton Früh, Majd Samman, Güliz Acker, Arend Koch, Helena Radbruch, Michael Scheel, Mike P. Wattjes, Julia Onken, Peter Vajkoczy, Nils Hecht, Jawed Nawabi, David Wasilewski   +17 more
wiley   +1 more source

Exploratory study on the impact of intraesophageal pressure on quality of life in patients following total gastrectomy: a retrospective cohort study

BMC Surgery
Background The usefulness of high-resolution impedance manometry (HRIM) in patients who underwent total gastrectomy with Roux-en-Y (R-Y) anastomosis has never been well validated.
Yoshihiro Saeki, Kazuaki Tanabe, Hiroshi Ota, Emi Chikuie, Yuki Takemoto, Nozomi Karakuchi, Akihiro Kohata, Osamu Miura, Eiichiro Toyama, Naruji Kugimiya, Hideki Ohdan   +10 more
doaj   +1 more source

Clinical characteristics, treatment response, and survival outcomes in melanoma patients with cavity carcinomatosis: A retrospective analysis

International Journal of Cancer, EarlyView.
What's New? Cavity carcinomatosis, a late manifestation of cancer, fuels tumor formation throughout a large area, most commonly the peritoneal and pleural cavities. The condition also can lead to resistance to otherwise effective treatment strategies.
Zhongqiao Lin, Li Zhu, Yuyang Huang, Lizhu Chen, Yuping Lu, Yu Chen, Jing Lin   +6 more
wiley   +1 more source

Move beyond free radical theory of aging

iMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source