Results 141 to 150 of about 13,002 (189)

Disorders of the Lower Esophageal Sphincter

Annual Review of Medicine, 1975
The junction of the esophagus and stomach in man is marked by a zone of elevated pressure which has been called the lower esophageal sphincter (LES) (1, 2). The purpose of this sphincter mechanism is to prevent regurgitation of gastric contents from a positive pressure cavity into the esophagus which maintains a pressure negative to the atmosphere (3 ...
R S, Fisher, S, Cohen
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The hypertensive lower esophageal sphincter

The American Journal of Surgery, 1996
This study defines the entity of the hypertensive lower esophageal sphincter (HLES) and its treatment, including surgical implications.Esophageal manometry was performed on 1,300 patients. Of these, 53 (4%) had HLES with resting pressure > 26.5 mm Hg, defined as the upper limit of normal resting LES pressure.
N, Katada, R A, Hinder, P R, Hinder, R J, Lund, G, Perdikis, R A, Stalzer, T R, McGinn   +6 more
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Lower esophageal sphincter pressure in histologic esophagitis

Digestive Diseases and Sciences, 1980
The fasting lower esophageal sphincter pressure of 18 normal volunteers was compared to 22 patients with symptoms and objective evidence of gastroesophageal reflux. Lower esophageal sphincter pressure was measured by rapid pull-through using an 8-lumen radially perfused catheter that sampled pressure every45 degrees around the circumference of the ...
R W, Welch, K, Luckmann, P, Ricks, S T, Drake, G, Bannayan, L, Owensby   +5 more
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The lower esophageal sphincter in health and disease

The American Journal of Surgery, 1988
The ability of the lower esophageal sphincter to protect the esophageal mucosa from exposure to gastric juice depends on its resting pressure, length exposed to abdominal pressure, and overall length. Mechanical incompetency of the sphincter can occur when one or more of these components fail. The purpose of this study was to measure manometrically the
G, Zaninotto, T R, DeMeester, W, Schwizer, K E, Johansson, S C, Cheng   +4 more
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Pathogenesis of Lower-Esophageal-Sphincter Incompetence

New England Journal of Medicine, 1973
Abstract Since patients with symptomatic gastroesophageal reflux have diminished lower-esophagealsphincter pressure, we studied the pathogenesis of this diminished sphincteric pressure. In 23 patients with symptomatic reflux as compared to 20 controls, the lower-esophageal-sphincter response to direct muscle stimulation by a parasympathomimetic drug ...
W H, Lipshutz, R D, Gaskins, W M, Lukash, J, Sode   +3 more
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The Lower Esophageal Sphincter

2014
The lower esophageal sphincter (LES) is a complex area of circular muscle on the distal esophagus and proximal stomach several centimeters in length. Together with the diaphragmatic crura and the structure of the angle of His, the LES makes up the backbone of the gastroesophageal reflux barrier.
Christina L. Greene, Steven R. DeMeester
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Transient lower esophageal sphincter relaxation

Gastroenterology, 1995
RAVINDER K. MITTAL,* RICHARD H. HOLLOWAY,* ROBERTO PENAGINI, § L. ASHLEY BLACKSHAW, t and JOHN DENT* *Department of Internal Medicine, University of Virginia, Charlottesville, Virginia; *Gastrointestinal Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia; and §Cattedra di Gastroenterologia, Istituto di Scienze Mediche, University ...
R. K. Mittal, R. H. Holloway, R. Penagini, A. Blackshaw, J. Dent   +4 more
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The Lower Esophageal Sphincter

Annals of Internal Medicine, 1975
Current concepts in physiology and pathophysiology of lower esophageal sphincteric mechanism are reviewed. With recent advances in manometric method for more accurate in-vivo human studies combined with in-vivo and in-vitro studies in animal models, there is much information regarding function of this sphincter.
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Resting pressures in the lower esophageal sphincter

The American Journal of Digestive Diseases, 1974
Interdeglutive pressures of the lower esophageal sphincter (LES) were studied by nonpullthrough techniques in 36 volunteers. Resting pressures did not remain at the high levels observed when the LES was entered. In 30 studies a gradual protracted decay ranging from 5 to 18 mm Hg was observed. These studies suggest that the LES may not pose a continuous
A A, Bloom, M, Stekelman, R, Varadee, S, Carvajal, M, Davidson   +4 more
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Lower Esophageal Sphincter Dysfunction in Achalasia

Gastroenterology, 1971
In patients with achalasia, lower esophageal sphincter (LES) dysfunction plays an important role in the impairment of esophageal emptying. To evaluate this dysfunction, the manometric characteristics of the LES were recorded for 20 normals and for 16 patients with achalasia, both before and after pneumatic dilation.
S, Cohen, W, Lipshutz
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