Results 161 to 170 of about 79,234 (256)

TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang, D. Q. Cai, Zhen Zhao, Zhixiang Jian, Mude Shi, Yajin Chen, Jueming Chen, Chunhua Qu, Diankui Cai   +8 more
wiley   +1 more source

Characterization of retrocopies in 663 individuals with esophageal squamous cell carcinoma. [PDF]

iScience
Zhuang X, Lian J, Zhou Y, Cui H, Tan J, Mao W, Wang L, Wang S, Cui Y, Zhang W.   +9 more
europepmc   +1 more source

Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro‐inflammatory tumor microenvironment in esophageal adenocarcinoma

International Journal of Cancer, Volume 159, Issue 2, Page 501-515, 15 July 2026.
What's new? Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor survival and variable response to perioperative chemotherapy. Although histopathological features correlate with outcomes, the relationship specifically between adherens junction (AJ) protein expression and treatment response in EAC remains uncertain.
Bastian Grothey, Heike Löser, Tillmann Bedau, Wolfgang Schröder, Christiane J. Bruns, Thomas Zander, Max Krämer, Reinhard Büttner, Alexander Quaas   +8 more
wiley   +1 more source

Metformin Use and Development of Esophageal Squamous Cell Carcinoma.

JAMA Netw Open
Xie SH, Santoni G, Birgisson H, von Euler-Chelpin M, Kauppila JH, Ness-Jensen E, Lagergren J.   +6 more
europepmc   +1 more source

Advances in multi-omics for esophageal squamous cell carcinoma: diagnostic, prognostic, and therapeutic perspectives. [PDF]

Protein Cell
Zhao D, He X, Guo Y, Wei H, Dong Z, Liu K.   +5 more
europepmc   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12 ‐Related Developmental Disorders

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1619-1650, July 2026.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Applications of artificial intelligence in postoperative surveillance and management of esophageal squamous cell carcinoma. [PDF]

Front Artif Intell
Li K, Qian Z, Mao J, Lu S, Zhang J, Han Y, Leng X.   +6 more
europepmc   +1 more source

Analysis of Histopathological Lesions and Their Correlation With Upper Gastrointestinal Endoscopic Findings: A Retrospective Study at a District Hospital in Ghana

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Although upper gastrointestinal (GI) endoscopy is a crucial diagnostic tool for evaluating lesions of the upper GI tract, its findings are not always definitive, necessitating histopathological confirmation. This retrospective study aimed to assess the spectrum of histopathological lesions and their correlation with ...
Prosper Adjei, Samuel Kyeremeh Adjei
wiley   +1 more source

The survival impact of upfront or sequential chemoradiotherapy in locally advanced esophageal squamous cell carcinoma. [PDF]

Front Oncol
Luo X, Peng F, Lin X, Li Y, Ding Z.
europepmc   +1 more source