Results 121 to 130 of about 101,346 (400)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Microbial Transglutaminase Increases Uptake and Translocation of Gliadin Peptides in the Human Intestinal Epithelium

Molecular Nutrition &Food Research, EarlyView.
The bacterial enzyme microbial transglutaminase (mTG) is widely used in the food industry as a technological aid to improve textural properties of a multitude of food products. mTG mimics the enzymatic function of human transglutaminase 2 (TG2) and may play a role in the pathogenesis of celiac disease.
Sebastian Stricker, Jan De Laffolie, Klaus‐Peter Zimmer, Silvia Rudloff   +3 more
wiley   +1 more source

What's new in the diagnosis and management of food allergy in children? [PDF]

, 2013
This article reviews the recent advances in the diagnosis and management of IgE mediated food allergy in children. It will encompass the emerging technology of component testing; moves to standardization of the allergy food challenge; permissive diets ...
Campbell, DE, Turner, PJ
core   +1 more source

Associations Between Nurse Staffing Levels and 30‐ and 60‐Day Readmissions for Acute Care Patients With Intellectual and Developmental Disability

Research in Nursing &Health, EarlyView.
ABSTRACT The purpose of this study was to examine the association between hospital nurse staffing levels and 30‐ and 60‐day readmissions among patients with intellectual and/or developmental disabilities (IDD). This cross‐sectional correlational study utilized secondary data from 595 acute care, nonfederal hospitals in California, Florida, New Jersey ...
Lynne S. Moronski, Eileen T. Lake, Matthew D. McHugh   +2 more
wiley   +1 more source

Trends in Endoscopist Reporting Rates of Eosinophilic Gastrointestinal Diseases in Japan Evaluated by the Japan Endoscopy Database Project. [PDF]

DEN Open
We analyzed 9,940,870 endoscopic procedures from the Japanese Endoscopy Database (2015–2023), identifying 9,669 eosinophilic gastrointestinal disease (EGID) cases. The prevalence of eosinophilic esophagitis, gastritis, and duodenitis increased significantly (p < 0.001), while enteritis and colitis remained unchanged (p = 0.136). EoE rose from 36 cases (
Miyaguchi K, Tsuzuki Y, Shiotani A, Tanaka K, Imaeda H.   +4 more
europepmc   +2 more sources

Rib Ewing Sarcomas in Children and Young Adults: A Large National Retrospective Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Purpose Ewing sarcoma (ES) is the most prevalent malignant thoracic tumor in childhood and young adults. This study reports the outcome of a national cohort treated in an international prospective trial for a localized rib ES, with a long follow‐up.
Audrey Claren, Alexandre Beige, Magali Morelle, Jérôme Doyen, Cyril Lervat, Luc Ollivier, Cécile Vérité, Perrine Marec‐Bérard, Maria Jolnerovski, Anne Ducassou, Valentine Martin, Line Claude, French Multidisciplinary Working Group on Bone Primary Tumours (GROUPOS), GSF (French Sarcoma Group), GETO (Bone Tumour Study Group) and SFCE (French Society for the Fight against Childhood and Adolescent Cancer and Leukaemia)   +14 more
wiley   +1 more source

Hiatoplasty with crura buttressing versus hiatoplasty alone during laparoscopic sleeve gastrectomy [PDF]

, 2017
Introduction. In obese patients with hiatal hernia (HH), laparoscopic sleeve gastrectomy (LSG) with cruroplasty is an option but use of prosthetic mesh crura reinforcement is debated.
Badiali, Danilo, Balla, Andrea, Paganini, Alessandro M., Palmieri, Livia, Quaresima, Silvia, Seitaj, Ardit, Ursi, Pietro   +6 more
core   +3 more sources

State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna, Amitava Mitra, Matthew L. Zierhut, Lilly East, Chandra Durairaj   +4 more
wiley   +1 more source

Endoscopic screening for precancerous lesions of the esophagus in a high risk area in northern Iran [PDF]

, 2014
Background: Esophageal squamous cell carcinoma (ESCC) is a major health problem in many developing countries, including Iran. ESCC has a very poor prognosis, largely due to late diagnosis.
Abnet, C., Dawsey, S.M., Etemadi, A., Ghasemi-Kebria, F., Khoshnia, M., Malekzadeh, R., Merat, S., Nickmanesh, A., Noorbakhsh, R., Norouzi, A., Pourshams, A., Poustchi, H., Roshandel, G., Semnani, S., Sotoudeh, M.   +14 more
core  

Esophageal remodeling in eosinophilic esophagitis

Current Opinion in Gastroenterology
Purpose of review Eosinophilic esophagitis (EoE) is a Th2 immune/antigen-mediated disorder characterized by esophageal dysfunction and eosinophilic inflammation. Worsening dysphagia and food impactions are significant complications associated with esophageal remodeling and fibrostenotic disease.
openaire   +2 more sources