Results 91 to 100 of about 306,493 (305)
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Rationale for the choice of operations in esophageal leiomyoma.
Medičnì Perspektivi, 2019 Operations on the esophagus occupy an important place in the surgery of the gastrointestinal tract, since this organ passes through three anatomical regions: the neck, thoracic and abdominal cavity.
V. V. Vasylkivskyi, V. G. Getman
doaj +1 more source
Surgical approaches to adenocarcinoma of the gastroesophageal junction: the Siewert II conundrum. [PDF]
, 2017 BACKGROUND: The Siewert classification system for gastroesophageal junction adenocarcinoma has provided morphological and topographical information to help guide surgical decision-making.
Berger, Adam C. +4 more
core +1 more source
Halofuginone is a Molecular Glue Degrader of Integrin β4
Advanced Science, EarlyView.Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong +8 more
wiley +1 more source
Patologìâ, 2012 We examined patients with symptoms of gastroesophageal reflux disease. Interconnection between morphofunctional state of esophageal and forestomach mucous membranes in patients with erosive form of gastroesophageal reflux disease was investigated ...
V.D. Markovskiy, V.V. Gargin, V.V. Sakal
doaj +1 more source
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
New totally intracorporeal reconstructive approach after robotic total gastrectomy. Technical details and short-term outcomes [PDF]
, 2017 AIM: To show outcomes of our series of patients that underwent a total gastrectomy with a robotic approach and highlight the technical details of a proposed solution for the reconstruction phase.
Cirocchi, Roberto +7 more
core +1 more source
Advanced Science, EarlyView.An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang +8 more
wiley +1 more source
Advanced Science, EarlyView.To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong +9 more
wiley +1 more source
Study of the Anatomy of the Alimentary Canal of Brochymena quadripustulata (Hemiptera:Pentatomidae) [PDF]
, 1980 An anatomical study of the alimentary canal and associated salivary apparatus was conducted for the pentatomid, Brochymena quadripustulata. The esophagus, ventriculus, pylorus, rectum, principal salivary glands and ducts are described and illustrated ...
Abell, David W. +2 more
core +2 more sources