Results 111 to 120 of about 340,355 (361)

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Jackhammer Esophagus as a Complication of Tonsillectomy and Adenoidectomy: A Case Report

Case Reports in Gastroenterology
Introduction: Tonsillectomy is a safe and common procedure. It has not been associated with the development of hypercontractile conditions of the esophagus. Jackhammer esophagus is a type of hypercontractile esophagus with vigorous contraction
W. Michael McDonnell, Alison Tewnion
doaj   +1 more source

Rationale for the choice of operations in esophageal leiomyoma.

Medičnì Perspektivi, 2019
Operations on the esophagus occupy an important place in the surgery of the gastrointestinal tract, since this organ passes through three anatomical regions: the neck, thoracic and abdominal cavity.
V. V. Vasylkivskyi, V. G. Getman
doaj   +1 more source

Paired Exome Analysis of Barrett’s Esophagus and Adenocarcinoma

Nature Genetics, 2015
Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) through a stepwise progression with loss of CDKN2A followed by TP53 inactivation and aneuploidy.
Matthew Stachler, A. Taylor-Weiner, Shouyong Peng, A. McKenna, A. Agoston, R. Odze, J. Davison, K. Nason, M. Loda, I. Leshchiner, Chip Stewart, P. Stojanov, Sara Seepo, M. Lawrence, Daysha Ferrer-Torres, Jules Lin, A. Chang, S. Gabriel, E. Lander, D. Beer, G. Getz, S. Carter, A. Bass   +22 more
semanticscholar   +1 more source

The feasibility of light microscopic measurements of intercellular spaces in squamous epithelium in the lower-esophagus of GERD patients

, 2011
P>The study aims to determine whether light microscopy can be used to accurately measure the diameters of intercellular spaces between squamous epithelial cells in the lower esophagus, and whether changes in this outcome measure can be used as a ...
L. Duan, H. Zhang, Cui, R., Yan, X., Xia, Z., Duan, L., J. Zhang, Z. Xia, Lin, S., Y. Xue, Zhou, L., Jin, Z., Z. Jin, R. Cui, S. Lin, Song, Z., L. Zhou, Z. Song, Zhang, H., Xue, Y., Zhang, J., X. Yan   +21 more
core   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Correlation between morphofunctional state of esophageal and forestomach mucous membranes in patients with erosive form of gastroesophageal reflux disease

Patologìâ, 2012
We examined patients with symptoms of gastroesophageal reflux disease. Interconnection between morphofunctional state of esophageal and forestomach mucous membranes in patients with erosive form of gastroesophageal reflux disease was investigated ...
V.D. Markovskiy, V.V. Gargin, V.V. Sakal
doaj   +1 more source

Whole-genome sequencing provides new insights into the clonal architecture of Barrett’s esophagus and esophageal adenocarcinoma

Nature Genetics, 2015
The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's esophagus, is poorly understood. Using whole-genome sequencing on 23 paired Barrett's esophagus and EAC samples, together with one in-depth ...
C. Ross-Innes, J. Becq, Andrew Warren, R. K. Cheetham, H. Northen, M. O'Donovan, S. Malhotra, M. di Pietro, S. Ivakhno, M. He, Jamie M J Weaver, A. Lynch, Z. Kingsbury, M. Ross, S. Humphray, D. Bentley, R. Fitzgerald, Stephen J Yeng Ian Shaun Sarah Vicki Richard Olga Jim Char Hayes Ang Welch Preston Oakes Save Skipworth Tucke, S. Hayes, Y. Ang, I. Welch, S. Preston, S. Oakes, V. Save, R. Skipworth, O. Tucker, J. Davies, C. Crichton, Christian Schusterreiter, T. Underwood, F. Noble, B. Stacey, J. Kelly, J. Byrne, Annette Haydon, D. Sharland, J. Owsley, Hugh Barr, J. Lagergren, J. Gossage, A. Davies, R. Mason, F. Chang, J. Zylstra, Grant Sanders, T. Wheatley, R. Berrisford, T. Bracey, C. Harden, David G. Bunting, T. Roques, J. Nobes, Suat Loo, M. Lewis, E. Cheong, O. Priest, S. Parsons, I. Soomro, Philip Kaye, J. Saunders, Vincent Pang, N. Welch, J. Catton, J. Duffy, K. Ragunath, L. Lovat, R. Haidry, Haroon Miah, S. Kerr, V. Eneh, R. Butawan, T. Roques, M. Lewis, E. Cheong, B. Kumar, L. Igali, Sharon P. Walton, A. Dann, P. Safranek, A. Hindmarsh, Vijayendran Sudjendran, M. Scott, A. Cluroe, A. Miremadi, B. Mahler-Araujo, B. Nutzinger, C. Peters, Z. Abdullahi, J. Crawte, S. Macrae, A. Noorani, R. Elliott, Lawrence Bower, Paul A. Edwards, S. Tavaré, Matthew Eldridge, J. Bornschein, M. Secrier, Tsun-Po Yang, J. R. O'Neill, Kasia Adamczuk, P. Lao-Sirieix, N. Grehan, Laura Smith, S. Lishman, D. Beardsmore, Sarah N Dawson   +106 more
semanticscholar   +1 more source

Relationship among modality of nodal metastasization and the presence/absence of intestinal metaplasia in the esophagus (BE) and in the stomach (GIM) for a adenocarcinoma of the esophagus and cardia (ADEC).

, 2012
Relationship among modality of nodal metastasization and the presence/absence of intestinal metaplasia in the esophagus (BE) and in the stomach (GIM) for a adenocarcinoma of the esophagus and cardia (ADEC)
Malvi D, Raulli G, ARAMINI BEATRICE, Lugaresi ML, Mattioli S., D'ERRICO ANTONIETTA, MATTIOLI SANDRO, D'Errico A, Aprile MR, RUFFATO ALBERTO, Ruffato A, Aramini B, LUGARESI MARIALUISA   +12 more
core  

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source