Results 91 to 100 of about 504,510 (309)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Unsettling bodies: Video essay as embodied research

open access: yes
This article proposes a fundamental new understanding of videographic research as an embodied practice and of the video essay as a “mingled body”: Not only does the video essay fuse multiple film materials and diverging artistic and scientific methods ...
Binotto, Johannes   +1 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

La ensayística latinoamericana como filosofía política

open access: yesCambios y Permanencias, 2017
The text is based on the recognition theme and on the critical analyses of romanticism in order to understand the complex relationship of Latin American societies with western modernity.
Hugo Celso Felipe AlbertoMansillaFerret d’Arau
doaj  

An Essay on Perfection

open access: yesIrish Mathematical Society Bulletin, 1987
The author introduces a generalization by means of the concepts of compactness and G-sets. Using some properties introduced of these new concepts, some general results are given about topological spaces which must contain perfect sets. To show the absence of perfect sets without some of these properties several counter-examples are given.
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Art, documentary and the essay film

open access: yes, 2015
On the precursors to the essay film, including Esfir ...
Leslie, Esther
core  

What can Essay Mills Teach us about AI

open access: yes, 2023
Academics are increasingly warned that cheating assisted by artificial intelligence (AI) could pose new challenges to the world of learning and teaching (Cotton et al., 2023).
Bagelman, Jen, Bagelman, Caroline
core  

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