Results 231 to 240 of about 290,234 (269)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Deciphering the Language of Assessment in Pharmacology Summative Written Assessments. [PDF]

open access: yesPharmacol Res Perspect
Kelly-Laubscher R   +3 more
europepmc   +1 more source

Effects of generative artificial intelligence on cognitive effort and task performance: study protocol for a randomized controlled experiment among college students. [PDF]

open access: yesTrials
Chen Y   +12 more
europepmc   +1 more source

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