Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Revista de Ciências Farmacêuticas Básica e Aplicada, 2021 Objectives: To evaluate the profile of the drugs for continuous use prescribed in Primary Health Care (PHC) in Santa Rosa / RS and to identify presence in the official lists of essential drugs. Methods: Cross-sectional, analytical and quantitative study,
Paula Lorenzoni Nunes +5 more
doaj
Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis [PDF]
, 2016 Vikram Saini +15 more
openalex +1 more source
Preventing Stock-outs of Antimalarial\ud Drugs in sub-Saharan Africa:Novartis’s SMS for Life [PDF]
, 2013 Malaria is curable. Although highly effective antimalarial drugs are available (up to 96% effective in the case of artemisinin-lumefantrine fixed-dose combinations), widespread stock-outs lead to deaths on a daily basis.
World Health Organization , (WHO)
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Reforma del sector salud y la política farmacéutica en Perú
Cadernos de Saúde PúblicaEste artículo analiza el Programa de Administración Compartida de Farmacias (PACFARM) y su articulación con la Política Farmacéutica en Perú, en el contexto de la reforma del sector salud. La ejecución de los diversos Programas de Medicamentos Esenciales
Carmen Phang Romero
doaj
Comparative study of efficacy and safety of Unani coded drug UNIM-904 with allopathic drug amlodipine in the treatment of essential hypertension [PDF]
, 2021 S Afza +7 more
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Price discrimination in essential medicines: evidence from International Drug Price Indicator Guide data [PDF]
, 2012 Michelle Hanlon, Ruihua Zhang
openalex +1 more source