Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Uptake of orphan drugs in the WHO essential medicines lists [PDF]
OBJECTIVE: We evaluated the uptake of medicines licensed as orphan drugs by the United States Food and Drug Administration (FDA) or European Medicines Agency (EMA) into the WHO Model list of essential medicines and the WHO Model list of essential ...
Huttner, Benedikt +6 more
core
Quality of Ayurvedic health care delivery in provinces of India: Lessons from essential drugs availability at State run Ayurveda dispensaries. [PDF]
J Ayurveda Integr Med, 2018 Rastogi S.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Effectiveness and safety of oral Chinese patent medicines as adjuvant treatment for unstable angina pectoris on the national essential drugs list of China: a protocol for a systematic review and network meta-analysis. [PDF]
BMJ Open, 2019 Hua Z +10 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Essential oils and drugs: interactions
, 2014 Schon seit jeher wurden ätherische Öle und deren Bestandteile in der Behandlung von vielen Krankheiten. Deren Verwendung und Bedeutung steigt beständig, sodass auch eine große Zahl an wissenschaftliche Studien mit dem Titel „Wechselwirkungen zwischen ...
Habib, George
core
Analysis of essential drugs lists of a regional healthcare coordination center in Rio Grande do Sul
O Mundo da Saúde, 2018 In Brazil municipalities are responsible for initiating the guarantee of access to essential medicines by selecting those that will be included in their lists. This study aimed to analyze how the Municipal Lists of Essential Medicines (MLEM) are prepared,
Mariele Salvi +3 more
doaj
The financial impact of the 'zero-markup policy for essential drugs' on patients in county hospitals in western rural China. [PDF]
PLoS One, 2015 Zhou Z +7 more
europepmc +1 more source