Results 121 to 130 of about 4,958,090 (306)

Potential conflicts in the fight against counterfeit drugs [PDF]

open access: yes
This analysis looks at the best way to deal with the proliferation of fake drugs, and considers the conflict that arises when government agencies aim to reduce the harmful effects of the fake medicine trade while the pharmaceutical firms seek profit ...
Luis Currais, Berta Rivera, Paolo Rungo
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Smoking, alcohol consumption and the use of drugs by pupils of schools for special education, vocational education and truants' projects 1990

open access: yes, 2007
In addition to an earlier survey "Smoking, alcohol consumption and the use of drugs by schoolchildren from the age of ten" (Steinmetz Archive Nr. P1057) among pupils of regular schools, pupils of schools for special education have been interviewed about ...
Zwart, W.M. de, Berben, E.G.M.J., Nederlands instituut voor alcohol en drugs, NIAD * Utrecht (primary investigator)
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Action Programme on Essential Drugs : 96-97 report of the biennium

open access: yes, 1998
WHO/DAP/MAC(10)/98.4108 ...
WHO Action Programme on Essential Drugs
core  

Reforma del sector salud y la política farmacéutica en Perú

open access: yesCadernos de Saúde Pública
Este artículo analiza el Programa de Administración Compartida de Farmacias (PACFARM) y su articulación con la Política Farmacéutica en Perú, en el contexto de la reforma del sector salud. La ejecución de los diversos Programas de Medicamentos Esenciales
Carmen Phang Romero
doaj  

Indian Essential Medicine List for mental disorders: Time to revisit

open access: yesAnnals of Medical Science and Research
Background: Management of mental health issues remains far from satisfactory. The majority of these mental health disorders can be effectively managed by ensuring the availability of quality drugs in appropriate dosage forms.
Divya Goel, Arnav Gupta
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Globalization and access to drugs : implications of the WTO/TRIPS Agreement

open access: yes, 1999
WHO/DAP/98.9 rev98 ...
WHO Action Programme on Essential Drugs   +1 more
core  

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