Results 241 to 250 of about 899,582 (283)

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension. [PDF]

BMC Pediatr
Sun L, Wang B, Yang D, Zhou W, Tang Y, Li X, Lv H, Hou M.   +7 more
europepmc   +1 more source

Lack of association of ACE2 G8790A gene mutation with essential hypertension in Chinese population: a meta-analysis involving 5260 subjects

, 2012
Yan-Yan eLi
openalex   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Genetic susceptibility to essential hypertension in the Chinese han population: a study on GAB1, GAB2, and GAB3 gene polymorphisms. [PDF]

BMC Cardiovasc Disord
Xiong J, Zhu L, Zhang W, Zhou Y, Yu Y, Xu M, Dong P, Fang Z, Chang W, Chen Y, Yao Y, Jin Y.   +11 more
europepmc   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Essential Hypertension as an Independent Risk Factor for Erosive Esophagitis: Insights From a Single-Center Retrospective Cohort Analysis. [PDF]

J Inflamm Res
Geng X, He T, Wang L, Zhang Z, Zhao T, Sun Y, Chang J, Duan Z.   +7 more
europepmc   +1 more source

Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients with Essential Hypertension: A Phase III, Multicenter, Double-Blind, Parallel-Group, Randomised study. [PDF]

J Hum Hypertens
Chi H, Zhang X, Ma S, Pan G, Lian X, Chen Y, Chen Y, Tang H, Liu Z, Mi P, Lin X.   +10 more
europepmc   +1 more source

Effect of N-terminal pro B-type natriuretic peptide levels on the efficacy and safety of esaxerenone vs trichlormethiazide for the treatment of Japanese patients with uncontrolled essential hypertension: a subanalysis of the EXCITE-HT study. [PDF]

Hypertens Res
Kario K, Ohishi M, Katsuya T, Shimosawa T, Shiosakai K, Furugori T, Taguchi T, EXCITE-HT investigators.   +7 more
europepmc   +1 more source

Vitamin D receptor gene rs2228570 (FOKI) polymorphism associated with essential hypertension in Iraqi patients

Aseel R. Jabir, Hussein A Saheb, Bassim I. Mohammad, Ahmed Sultan, Sinaa Abdul Amir Kadhim, Asma A Swadi   +5 more
openalex   +1 more source