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The Lancet, 2007
Essential hypertension can be defined as a rise in blood pressure of unknown cause that increases risk for cerebral, cardiac, and renal events. In industrialised countries, the risk of becoming hypertensive (blood pressure >140/90 mm Hg) during a lifetime exceeds 90%.
Messerli, FH, Williams, B, Ritz, E
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Essential hypertension can be defined as a rise in blood pressure of unknown cause that increases risk for cerebral, cardiac, and renal events. In industrialised countries, the risk of becoming hypertensive (blood pressure >140/90 mm Hg) during a lifetime exceeds 90%.
Messerli, FH, Williams, B, Ritz, E
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Mechanisms in Essential Hypertension
Diseases of the Chest, 19621. There are two basic interdependent mechanisms responsible for the development of essential hypertension. One is a defect in the catecholamine storage complex resulting in a small store and the other an increase in the sodium concentration in vascular smooth muscle. The former, in our view, is the basic hereditary defect although its exact chemical
M, MENDLOWITZ +3 more
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Guanabenz in essential hypertension
Clinical Pharmacology & Therapeutics, 1977Fifty‐five patients with mild to moderately severe essential hypertension were treated with guanabenz (2,6‐dichlorobenzylidene aminoguanidine acetate) in doses from 4 to 16 mg twice daily in a randomized, placebo‐controlled study. The patients treated with placebo in the initial phase of the study were subsequently treated with guanabenz.
F G, McMahon +4 more
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The catecholamines in essential hypertension
American Heart Journal, 1976The evidence for involvement of the catecholamines and their metabolites in essential hypertension is presented. Labile and established essential hypertension should be considered individually in this respect, although they may exist separately or together.
M, Mendlowitz, N D, Vlachakis
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THE NATURE OF ESSENTIAL HYPERTENSION
The Lancet, 1959When Hamilton, Pickering, Fraser Roberts and Sowry published their four papers in 1954 I accepted the authority of Pickering and was blinded by the treatment of mathematical data to 8 places of decimals. It never occurred to me to question either the reliability of their data or the validity of their treatment of them, and I accepted for several years ...
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The Adolescent With Essential Hypertension
American Journal of Kidney Diseases, 1985Clinical features in a comparably studied group of hypertensive and normotensive adolescents are described. Hypertensive hyperreninemia occurred in four of 28 hypertensive adolescents; suppressed plasma renin activity was found in five of 27 hypertensive adolescents.
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Genetics of essential hypertension
Journal of the American Academy of Nurse Practitioners, 2005PurposeTo inform healthcare providers of the genetics involved in the development of essential hypertension and to illustrate the role the healthcare provider has in the management of patients with essential hypertension.Data sourcesResearch‐based articles in the medical literature, selected published literature in refereed journals, and Internet sites.
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Cations in essential hypertension
The American Journal of Cardiology, 1987Sodium intake has been linked to the development and perpetuation of hypertension for almost a century. Nevertheless, considerable controversy over this relationship remain. More recently, the other major body cations, potassium, calcium and magnesium, have also been implicated.
M H, Maxwell, A U, Waks
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Platelets in essential hypertension
Thrombosis Research, 1993The ultrastructure and adenosine diphosphate induced aggregatory response of platelets of 39 patients with essential hypertension have been studied. Both, transmission and scanning electron microscopy showed the co-existence of various morphological forms of platelets suggestive of activation.
S, Nityanand +5 more
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Management of essential hypertension
Expert Opinion on Pharmacotherapy, 1999Hypertension, in spite of a very high prevalence, remains undertreated. This is not due to a lack of effective therapeutic modalities. Non-pharmacological treatments can be effective in many patients. If those treatments fail to reduce blood pressure sufficiently, the physician can choose between numerous classes of antihypertensive agents.
C, Terpening, J G, Gums, K, Grauer
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