Results 171 to 180 of about 195,292 (253)

The Political Economy of the World Health Organization Model Lists of Essential Medicines. [PDF]

Milbank Q
Jenei K.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Correction: Availability, affordability, and associated factors of essential medicines in primary health care facilities of the Wolaita zone, southern Ethiopia: implication for access, a cross-sectional study, 2022. [PDF]

Res Health Serv Reg
Adale A.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

National availability, prices and affordability of essential medicines: a comprehensive analysis using WHO/HAI methodology in Chad. [PDF]

Pan Afr Med J
Ragomzingba FEZ, Haroun SH, Ngabéré C, Borgnol A, Yoyammel M, Kadai AO, Efobi JE, Tamuzi JL, Katoto PMC, Wiysonge CS, Anya BM, Zongo L.   +11 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Measuring the value of the WHO Model list of essential medicines. [PDF]

Bull World Health Organ
Peacocke EF, Dale E, Mori AT, Koduah A, Gopinathan U.   +4 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Comprehensive framework for prioritisation of health technologies for updating of essential medicines list to primary healthcare engaging stakeholders: a mixed-methods study protocol. [PDF]

BMJ Open
de Oliveira JC, Paganelli MO, de Oliveira AM, Carrillo JFS, Moura MDG, Yamauti SM, Lopes LC.   +6 more
europepmc   +1 more source