Results 181 to 190 of about 195,292 (253)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Medicines not recommended for inclusion in the who essential medicines list: a retrospective observational study. [PDF]

Front Med (Lausanne)
Costa E, Del Grosso V, Cappello B, Genazzani AA, Huttner B, Leufkens HGM, Magrini N, Nonino F, Wirtz VJ, van den Ham HA, Moja L.   +10 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

When did medicines become essential?

Bulletin of the World Health Organization, 2010
Jeremy A Greene
doaj  

Availability, affordability, and associated factors of essential medicines in primary health care facilities of the wolaita region, southern Ethiopia: implication for access, a cross-sectional study, 2022. [PDF]

Res Health Serv Reg
Adale A.
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

On paper; in practice: measuring compliance with official pricing policies in a large field study of essential medicines in Indonesia. [PDF]

J Pharm Policy Pract
Rahmawati A, Ramadaniati HU, Anggriani Y, Nathanial W, Pisani E.   +4 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Inventory management performance of essential medicines in public health facilities of Jimma Zone, Southwest Ethiopia. [PDF]

PLOS Glob Public Health
Bekele A, Boche B, Anagaw YK, Ayenew W, Worku MC, Geremew DT, Minwagaw T, Melkamu E, Woldeyohanins AE, Tefera BB, Duguma M.   +10 more
europepmc   +1 more source

Taxing essential medicines is inhuman

Indian Journal of Pharmacology, 2013
openaire   +3 more sources