Results 121 to 130 of about 3,279,270 (293)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Composition Operators on Cesàro Function Spaces
Journal of Function Spaces, 2014 The compact, invertible, Fredholm, and closed range composition operators are characterized. We also make an effort to compute the essential norm of composition operators on the Cesàro function spaces.
Kuldip Raj, Suruchi Pandoh, Seema Jamwal
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Essential Norms of Pointwise Multipliers in the Non‐Algebraic Setting
Mathematische NachrichtenABSTRACT Motivated by some recent results, but also referring to recognized classics, we compute the essential norm and the weak essential norm of multiplication operators acting between two distinct Köthe spaces both defined over the same ‐finite measure space.
Tomasz Kiwerski, Jakub Tomaszewski
openaire +2 more sources
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
On the Complementarity between Law and Social Norm: A Model Analysis with Special Reference to the Liability Rule for Tort [PDF]
How the law and the social norm interact with each other in the legalized modern society, whether the law completely replaces the pre-existing social norm or they coexist, and whether their interaction achieves an efficient system of social rules or ...
Atsushi Tsuneki, Yoshinobu Zasu
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
(SNP123) Norm Trout and Bob Johnson
, 1977 Records a conversation between Norm Trout and Bob Johnson, employees of the National Park Service at Shenandoah National Park. The men discuss various issues concerning access to the park, trail conditions and early settlers to the region, including Bob ...
Trout, Norm
core
Conformity to social norm interventions is not amplified in tighter nations
Communications PsychologySocial norms have a reliable and oftentimes strong influence on individual attitudes and behaviors across environmental and other domains. This influence has been theorized to differ by cultural tightness—the extent to which people adhere to shared ...
Jane Acierno +7 more
doaj +1 more source