Results 61 to 70 of about 6,272,398 (259)

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Chemical Composition of Fruit Essential Oil of Endemic

open access: yesNatural Product Communications, 2016
The water distilled essential oil (EO) from the fruits of Malabaila pastinacfolia Boiss & Balansa (Apiaceae), an endemic species from Turkey, was analyzed using GC-FID and GC-MS systems.
Nurhayat Tabanca
doaj   +1 more source

Chemical Composition, Antioxidant and Antimicrobial Properties of Essential Oil and Extracts from Heracleum sphondylium L

open access: yes, 2016
© 2016 Har Krishan Bhalla & Sons. The present study describes chemical composition of essential oil, total phenolic and flavonoid content and in vitro antioxidant and antimicrobial activity of essential oil and various extracts from Heracleum ...
Randelovic, Vladimir   +6 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Essential Oil Composition of the Aerial Parts of

open access: yesNatural Product Communications, 2008
The essential oil composition of the aerial parts of Bupleurum candollii Wall. ex DC. was analyzed by GC and GC/MS. A total of 19 compounds have been identified, representing 91.8% of the total oil.
Rajesh K. Joshi, Chitra Pande
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Composition of the Essential Oil of from Tajikistan

open access: yesNatural Product Communications, 2011
Origanum tyttanthum Gontsch. was collected from two different sites in south-central Tajikistan. The essential oils were obtained by hydrodistillation and analyzed by gas chromatography – mass spectrometry.
Farukh S. Sharopov   +2 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Chemical Composition of subsp. Essential Oil from Croatia

open access: yesNatural Product Communications, 2013
The aerial parts of Hypericum richeri Vill. subsp. grisebachii (Boiss.) Nyman were collected from two different locations in Croatia and subjected to hydrodistillation.
Igor Jerković   +5 more
doaj   +1 more source

Variation in essential oil composition of coriander (Coriandrum sativum L.) varieties cultivated in two different ecologies

open access: yes, 2017
Coriander, Coriandrum sativum L, is an important medicinal plant belonging to Apiaceae family, which is grown in many parts of Turkey. In this study, essential oil and composition of 6 Turkish coriander cultivars (Gamze, Arslan, Erbaa, Pelmus, Kudret ...
Elmastas, Mahfuz   +2 more
core   +1 more source

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