Results 71 to 80 of about 3,046,243 (224)

Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat

Haematologica, 2020
In a phase II study, the telomerase inhibitor imetelstat induced rapid hematologic responses in all patients with essential thrombocythemia who were refractory to or intolerant of prior therapies.
E. O. Leibundgut, M. Haubitz, B. Burington, O. Ottmann, G. Spitzer, O. Odenike, M. McDevitt, A. Röth, D. Snyder, G. Baerlocher   +9 more
semanticscholar   +1 more source

The role of oxidative stress in essential thrombocythemia [PDF]

Archives of the Balkan Medical Union, 2018
In patients with myeloproliferative neoplasms (MPNs), including essential thrombocythemia, current studies have demonstrated a JAK2V617F-dependent reactive oxygen species (ROS) elevation partially mediated by a decrease in catalase expression associated ...
Cornel Moisă, Mihnea-Alexandru Găman, Emilia Georgiana Pascu, Oana Cătălina Drăgușin, Alexandru Dan Assani, Mirela-Elena Epîngeac, Amelia-Maria Găman   +6 more
doaj  

Diagnosis and Management of Essential Thrombocythemia: A Comprehensive Review [PDF]

Documenta Haematologica
Myeloproliferative neoplasms, including essential thrombocythemia, are characterized by clonal proliferations of hematopoietic stem cells, leading to an increase in mature myeloid lineage cells.
Sandra LAZAR, Despina Calamar POPOVICI, Oana SARAU, Hortensia IONITA, Claudiu Octavian IONITA, Dacian Nicolae OROS, Ioana IONITA   +6 more
doaj   +1 more source

Health Distress and Challenges in Patients With Myeloproliferative Neoplasms During Follow‐Up Consultations at the Outpatient Clinic: A Phenomenological Study

Cancer Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background Myeloproliferative neoplasms (MPN) present significant management challenges as their constitutional symptoms greatly affect patients' quality of life. While current literature addresses hematological aspects, the full symptom burden and post‐clinic challenges for adult patients, especially in outpatient settings, remain unclear ...
Yating Liu, Jinying Zhao, Qianqian Zhang, Qingyan Gao, Yayun Cao, Jia He, Lihua Han, Yandi Wang, Qian Yang, Wenjun Xie   +9 more
wiley   +1 more source

Successful management of VTE with essential thrombocythemia and cavernous transformation of the portal vein in early pregnancy: a case report

BMC Women's Health
Due to the thrombohemorrhagic potential of essential thrombocythemia, pregnancy complicated by essential thrombocythemia should be recognized as a risk factor for obstetric complications.
Xin Kang, Shibin Hong, Chengxi Tan, Wen Di, Ning Zhang   +4 more
doaj   +1 more source

Thromboembolic complication in Essential Thrombocythemia

The Pan African Medical Journal, 2012
The presenting symptoms of patients with essntial thrombocythemia are quite variable. After detection of thrombocytosis about 13 to 37 percent of patients relate symptoms due to hemorrhagic event, and about 22 to 84 percent of patients report ...
Zahra Mozaheb
doaj   +1 more source

Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia

Haematologica, 2009
Background Most cell types, including blood - and vascular cells, produce microparticles upon activation. Since cellular microparticles are known to be elevated in thromboembolic diseases, we hypothesized a role for microparticles in the pathogenesis of ...
Marijke C. Trappenburg, Muriel van Schilfgaarde, Marina Marchetti, Henri M. Spronk, Hugo ten Cate, Anja Leyte, Wim E. Terpstra, Anna Falanga   +7 more
doaj   +1 more source

Bilateral Chylothorax due to Lymphatic Reflux Into the Visceral Pleura From Thoracic Duct Obstruction

Respirology Case Reports, Volume 13, Issue 11, November 2025.
We report a rare case of bilateral idiopathic chylothorax that may have resulted from retrograde lymphatic flow into the lungs secondary to thoracic duct obstruction. Lymphangiography and follow‐up CT demonstrated contrast accumulation in the perihilar lymphatic channels and lung parenchyma, supporting the hypothesis of retrograde lymphatic flow rather
Minako Shimaya, Yoshiaki Tanaka, Hitoshi Takeuchi, Kozo Yoshimori, Shoji Kudoh   +4 more
wiley   +1 more source

Acute megakaryoblastic transformation from essential thrombocythemia

Human Pathology: Case Reports, 2017
Essential thrombocythemia (ET) is a Philadelphia chromosome-negative myeloproliferative neoplasm characterized by sustained thrombocytosis. Its transformation into acute leukemia is a rare event (5% at 20 years).
Tariq M. Roshan, Ashish B. Rajput, Philip Berardi, Ruth Padmore   +3 more
doaj   +1 more source

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson, King Long Hannah Lee, Megan Dietz, Sarah Guess, Laura White, Mara S. Varvil   +5 more
wiley   +1 more source