Results 81 to 90 of about 3,046,243 (224)

TIE1 Promotes Primary Tumor Growth by Inhibiting Apoptosis and Activating the AKT‐p70S6K Signaling Pathway in Breast Cancer

Genes to Cells, Volume 30, Issue 6, November 2025.
Highly lung‐metastatic breast‐cancer cells with elevated TIE1 expression exhibit increased tumorigenicity. In primary tumors, TIE1 undergoes cleavage and promotes cancer cell survival by activating the AKT–p70S6K signaling pathway. ABSTRACT Triple‐negative breast cancer (TNBC) is the most aggressive molecular subtype among all breast cancer types.
Kazushi Azuma, Takaya Matsuyama, Shinya Watanabe, Kentaro Semba, Jun Nakayama   +4 more
wiley   +1 more source

Atypical Myocardial Infarction with Apical Thrombus and Systemic Embolism: A Rare Presentation of Likely JAK2 V617F-Positive Myeloproliferative Neoplasm

Case Reports in Oncological Medicine, 2020
A few types of myeloproliferative neoplasms may be significant for Janus-associated kinase 2 mutation, JAK2 V617F, including polycythemia vera, essential thrombocythemia, and primary myelofibrosis.
Muhammed Atere, Rana Al-Zakhari, Jennifer Collins, Francesco Rotatori, Lloyd Muzangwa   +4 more
doaj   +1 more source

Prognostic factors for thrombosis, myelofibrosis, and leukemia in essential thrombocythemia: a study of 605 patients

Haematologica, 2008
Background Essential thrombocythemia is a chronic myeloproliferative disorder; patients with this disorder have a propensity to develop thrombosis, myelofibrosis, and leukemia.Design and Methods We studied 605 patients with essential thrombocythemia ...
Francesco Passamonti, Elisa Rumi, Luca Arcaini, Emanuela Boveri, Chiara Elena, Daniela Pietra, Sabrina Boggi, Cesare Astori, Paolo Bernasconi, Marzia Varettoni, Ercole Brusamolino, Cristiana Pascutto, Mario Lazzarino   +12 more
doaj   +1 more source

Comparison of Clinical and Hematological Parameters of Janus Kinase 2, Calreticulin or Myeloproliferative Leukemia Virus Oncogene Mutant Essential Thrombocythemia and Triple-Negative Essential Thrombocythemia [PDF]

, 2022
Jale Yıldız, Hikmettullah Batgi
openalex   +1 more source

CALR Type 1‐Like Mutations Increase Endoplasmic Reticulum Free Ca2+ and Induce ERK1/2 Activation Independent of Thrombopoietin Receptor Activation

Cell Biology International, Volume 49, Issue 10, Page 1262-1273, October 2025.
ABSTRACT Calreticulin is a multifunctional protein found in the endoplasmic reticulum lumen that is important for calcium homeostasis and glycoprotein folding. Mutations in exon 9 of the CALR gene are the second most common genetic cause of myeloproliferative neoplasms.
Mifra Faiz, Caitlin Dunstan‐Harrison, Elizabeth C. Ledgerwood   +2 more
wiley   +1 more source

Multiple venous and arterial thromboses of the gallbladder causing acute cholecystitis. A previously undescribed complication of essential thrombocythemia(†)(†)Supported in part by Fundación Clínica Médica Sur.

Annals of Hepatology, 2011
Well established complications of essential thrombocythemia are multiple thrombohemorrhagic phenomena in various abdominal organs. We describe the case of a 22 year old man with essential thrombocythemia and thrombosis of the mesenteric and splenic veins
Gabriela Picón-Coronel, Fredy Chablé-Montero, Arturo Ángeles-Ángeles, Jorge Albores-Saavedra, Dr.   +3 more
doaj   +1 more source

Essential Thrombocythemia's Role in the Complex Landscape of Vasculitis: A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Peripheral gangrenes have been sporadically documented as the initial presentation of essential thrombocythemia (ET), as exemplified in the preceding case reports. Nevertheless, the prevalence of vasculitis‐induced skin problems as the primary indication of ET has not been extensively examined.
Mohammad Reza Jafari Nakhjavani, Seyedeh‐Tarlan Mirzohreh, Sousan Kolahi, Mehrzad Hajialilo, Mehdi Jafarpour, Arezou Ghassembaglou, Mir Ali Sattary Oskouie, Tala Pourlak, Sepideh Tahsini Tekantapeh   +8 more
wiley   +1 more source

Essential Thrombocythemia Complicated by Addison's Disease: A Case of Overlapping Endocrine and Hematological Disorders

Hematology, Transfusion and Cell Therapy
This case report delves into the intricacies of managing a patient diagnosed with both essential thrombocythemia and Addison's disease, illustrating the challenges and importance of an integrated approach to complex, coexisting conditions.
Meryem SENER, Kaan NISANOGLU, Candas MUMCU, Bengisu Ece DUMAN, Berra Nur ISCI, Emre BAL, Irem KABALCI KADIOGLU, Birol GUVENC   +7 more
doaj   +1 more source

Significant increase in the apparent incidence of essential thrombocythemia related to new WHO diagnostic criteria: a population-based study

Haematologica, 2009
To observe the effect of the new World Health Organization (WHO) criteria on the incidence of myeloproliferative neoplasms, we performed a retrospective study of a population-based registry in the Côte d’Or area, France, from 1980 to 2007. A total of 524
François Girodon, Gilles Bonicelli, Céline Schaeffer, Morgane Mounier, Serge Carillo, Ingrid Lafon, Paule Marie Carli, Inès Janoray, Emmanuelle Ferrant, Marc Maynadié   +9 more
doaj   +1 more source

Moyamoya syndrome in an adult with essential thrombocythemia

Neurology International, 2011
Moyamoya syndrome is a rare cerebrovascular disorder characterized by progressive occlusion of the supraclinoid internal carotid artery and proximal portions of the anterior and middle cerebral arteries resulting in an extensive network of collateralized
Marc Lazzaro, Elizabeth J. Cochran, Demetrius K. Lopes, Shyam Prabhakaran   +3 more
doaj   +1 more source