Results 101 to 110 of about 1,306,145 (264)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Towards implementing workflows for essential biodiversity variables at a European scaleZenodo

Global Ecology and Conservation
Biodiversity is declining, prompting new multilateral treaties and environmental legislation. To track the progress of these efforts, a comprehensive monitoring network is essential.
Maria Lumbierres, Marija Milanović, Pedro Beja, Aletta Bonn, Tom D. Breeze, Lluís Brotons, Néstor Fernández, Jessica Junker, Camino Liquete, Anne Lyche Solheim, Alejandra Morán Ordóñez, Francisco Moreira, Joana Santana, Stacy Shinneman, Bruno Smets, Henrique M. Pereira, Jose W. Valdez, Roy H.A. van Grunsven, W. Daniel Kissling   +18 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genome‐Wide Diversity in Lowland and Highland Maize Landraces From Southern South America: Population Genetics Insights to Assist Conservation

Evolutionary Applications
Maize (Zea mays ssp. mays L.) landraces are traditional American crops with high genetic variability that conform a source of original alleles for conventional maize breeding.
Pia Guadalupe Dominguez, Angela Veronica Gutierrez, Monica Irina Fass, Carla Valeria Filippi, Pablo Vera, Andrea Puebla, Raquel Alicia Defacio, Norma Beatriz Paniego, Veronica Viviana Lia   +8 more
doaj   +1 more source

Exploring Recent (1991–2020) Trends of Essential Climate Variables in Greece

Atmosphere
Europe and the Mediterranean are considered climate change hot spots. This is the reason why this paper focuses on the analysis of the trends of essential climate variables in a Mediterranean country, Greece.
Konstantinos Lagouvardos, Stavros Dafis, Vassiliki Kotroni, George Kyros, Christos Giannaros   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The Italian effort toward a coordinated observation of Essential Variables (EOV, ECV, EBV) in European Marine Environments. Long-term observation in the central Mediterranean seas and Italian coasts

Frontiers in Marine Science
Monitoring Essential Ocean, Climate, and Biodiversity Variables (EOVs, ECVs and EBVs) collected through the marine Research Infrastructures (RIs) is critical for assessing environmental status, improving scientific knowledge and defining environmental ...
Simone Toller, Emilio Urbinati, Debora Bellafiore, Caterina Bergami, Francesca De Pascalis, Marcello G. Magaldi, Marco Bellacicco, Federico Bellati, Maristella Berta, Angelo Boccacci, Roberto Bozzano, Fabio Brunetti, Giuseppa Buscaino, Carolina Cantoni, Vanessa Rossana Cardin, Carmela Caroppo, Lorenzo P. Corgnati, Alessio Corsi, Silvio Davison, Giuseppe Denti, Andrea Di Macco, Davide Embriaco, Michele Giani, Santina Giandomenico, Giordano Giorgi, Zoi Kokkini, Giovanni La Forgia, Daniele Lagomarsino-Oneto, Carlo Mantovani, Simone Marini, Elena Mauri, Emanuele Organelli, Francesco Paladini De Mendoza, Elena Bianca Papale, Sara Pensieri, Antonella Petrocelli, Jaime Pitarch, Angela Pomaro, Giorgio Riccobene, Francesco Riminucci, Francesco Riminucci, Fernando Rubino, Gian Marco Scarpa, Katrin Schroeder, Roberta Sciascia, Riccardo Tagliavini, Rosalia Santoleri   +46 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source