Results 81 to 90 of about 18,160,584 (274)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Comparative Literature: Can This Marriage Be Saved? [PDF]
, 2018 "With comparative literature becoming American world literature or globalized cultural studies, comparatists need to ask themselves whether they want to remain in such a dysfunctional relationship.
Figueira, Dorothy
core
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Московский журнал международного праваINTRODUCTION. The article essentially deals with the legal mechanism of challenging the Eurasian Economic Commission’s (EEC) acts in the sphere of antimonopoly regulation by individuals in relation to their right of access to justice.MATERIALS AND ...
S. V. Maksimov, A. A. Filimonenko
doaj +1 more source
A Comparative Study of German and French Security Behaviors in Light of Strategic Culture [PDF]
Faṣlnāmah-i Pizhūhish/hā-yi Rāhburdī-i SiyāsatIntroductionGermany and France, as two national actors, engage in processes of security convergence at both regional and extra-regional levels. However, the prevailing structural approach to analyzing security behaviors has proven insufficient and only ...
Gholamali Chegnizadeh +2 more
doaj +1 more source
Centre for Comparative Literature, University of Toronto
, 2009 Discusses the 40th anniversary of the University of Toronto\u27s Centre for Comparative ...
Valdés, Mario J.
core
The Comparative Impetus: Thoughts on the Changing Landscape of Comparative Literature [PDF]
, 2014 "The engine of Comparative Literature is moving along, but where it goes from here remains largely dependent on acknowledging the forces that drive it, not least including the ever-increasing diversity that characterizes the backgrounds, orientations ...
Ylagan, Christian
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
A Systematic Review of Money Creation Theories in Conventional Banking [PDF]
تحقیقات مالی اسلامی (پیوسته)1. Introduction and ObjectiveUnderstanding the mechanism of money creation within modern banking systems constitutes one of the most fundamental issues in both monetary economics and Islamic jurisprudence.
Mohammad Talebi +3 more
doaj +1 more source