Results 161 to 170 of about 2,962 (246)

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

Ligand‐Directed Molecular Beacons as Turn‐On Fluorescent Probes for Sensing Cell‐Surface Receptor‐Ligand Interactions

Angewandte Chemie, EarlyView.
Multivalent, ligand‐directed molecular beacons enable fluorescence turn‐on detection of cell‐surface receptors in living cells. The probes strongly engage closely spaced membrane receptors and exhibit conformation‐dependent fluorescence enhancement at the cell surface, enabling wash‐free receptor imaging, inhibitor screening, and functional evaluation ...
Noa Oppenheimer‐Low, Denis Shpalter, Suraj Toraskar, Martín López‐Vidal, Ziv Porat, Inna Goliand, Ekaterina Petrovich‐Kopitman, Noga Kozer, Haim Michael Barr, Alla H. Falkovich, Leila Motiei, David Margulies   +11 more
wiley   +2 more sources

Pseudomonas aeruginosa adaptation and persistence in the aspergilloma microbiome revealed by integrated multi-omics. [PDF]

G3 (Bethesda)
Ribeiro MM, Liu C, Xu JF, Liang S, Goldman GH.   +4 more
europepmc   +1 more source

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa‐I Trial

Annals of Neurology, EarlyView.
In this post hoc analysis of the ANNEXa‐I trial (n = 434), we evaluated non‐contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) –associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12.5 mL or ≥ 35% increase in hematoma volume) occurred in 31.8 ...
Koji Tanaka, Umberto Pensato, Mohamed Alshamrani, Aristeidis H. Katsanos, Pargol Balali, Sucharita Ray, Scott E. Kasner, Jan Beyer‐Westendorf, Danilo Toni, David J. Seiffge, Carlos Molina, David Tanne, Anna Członkowska, Arne G. Lindgren, Daniel Bereczki, Else C. Sandset, Georgios Tsivgoulis, Hanne Christensen, Jonathan M. Coutinho, Peter Verhamme, Pierre Amarenco, Robin Lemmens, Roland Veltkamp, Saskia Middeldorp, Thompson Robinson, Truman J. Milling, Wilfried Lang, Vitor Tedium‐Cruz, Mark Crowther, Lizhen Xu, Mikael Knutsson, Per Ladenvall, John W. Eikelboom, Mukul Sharma, Ashkan Shoamanesh, Andrew M. Demchuk   +35 more
wiley   +1 more source

Engineering Atomically Precise Cu4I4 Nanoclusters With Integrated Adsorption and Hydrogenation Functions for Efficient Photocatalytic Nitrate‐to‐Ammonia Conversion

Angewandte Chemie, EarlyView.
Efficient photocatalytic nitrate‐to‐ammonia conversion is achieved over an atomically precise Cu4I4 motif through dual‐site cooperation. Lewis‐acidic Cu centers promote nitrate adsorption and activation, while adjacent I sites facilitate active hydrogen generation for stepwise hydrogenation.
Wanting Zhang, Yuehua Li, Junjie Jin, Chunwei Dong, Xi Cao, Xingchi Li, Xuanjun Wu, Jiaqi Wang, Atta Ullah, Gaspar Ferreyra Vaggione, Rodrigo A. Iglesias, Yun Chen, Emiliano Cortés, Dengsong Zhang   +13 more
wiley   +2 more sources

Quasi-Simultaneous Detection of Ammonia and Nitrous Oxide by Photoacoustic Phase-Resolved Method: A Proof-of-Concept. [PDF]

Anal Chem
Santos DDS, Mota L, Lima GR, da Matta EC, Alvarenga TL, Bahr MS, Esquef IA, Wolff M, da Silva MG.   +8 more
europepmc   +1 more source

Fusión política de los estados de Israel y Palestina

, 2023
openaire   +1 more source

High‐Pressure Synthesis of Quantum‐Stabilised Manganese Superhydride MnH7

Angewandte Chemie, EarlyView.
Superhydrides are a rarity in transition metal hosts. Through high‐pressure, high‐temperature diamond anvil cell studies, the most hydrogen‐rich transition metal hydride, MnH7${\rm MnH}_7$ has been synthesised. Density functional theory calculations demonstrate that zero‐point energy stabilises the crystalline structure that MnH7${\rm MnH}_7$ adopts ...
Mikhail A. Kuzovnikov, Hannah A. Shuttleworth, Israel Osmond, Huixin Hu, Elvita Meskauskaite, Bole Chen, Callum Stevens, Andrew Huxley, Andreas Hermann, Miriam Peña‐Alvarez, Ross T. Howie   +10 more
wiley   +2 more sources

Antifungal and Anti-Oomycete Potential of Ag₂S-S Janus and Ag Nanoparticles Synthesized with Non-Toxic Agents and Their Application to Control <i>Fusarium</i> Wilt of Tomato. [PDF]

Int J Mol Sci
Sánchez-Fernández RE, Tapia MC, Canseco-González D, Aguilar-Moreno GS, Aguilar-Méndez MA, Ascencio F, Rojas-Sandoval L, Navarro Cerón E.   +7 more
europepmc   +1 more source

Identification and characterization of non-canonical azole antifungal resistance pathways in <i>Aspergillus fumigatus</i>. [PDF]

mBio
Delbaje E, Ribeiro MM, Bitencourt RdOB, Lagrou K, Hubka V, Pontes L, Schreiber AZ, Robbins N, Cowen LE, Dos Reis TF, Goldman GH.   +10 more
europepmc   +1 more source