Unveiling empathy determinants across borders: a comparative analysis of medical students from two geo-sociocultural backgrounds. [PDF]
BMC Med EducBalbinot F +6 more
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
The "Prudente Plan:" a São Paulo plan for the fight against cancer in Brazil, 1934-1954. [PDF]
Hist Cienc Saude ManguinhosMessora EAK, Mota A.
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Nursing response and COVID-19 mortality in rural municipalities in southern Brazil. [PDF]
Rev Bras EnfermSouto LHD +6 more
europepmc +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Eradicating the germs of pauperism: the political economy of the British sanitary movement in the 1830s and 1840s. [PDF]
Hist Cienc Saude ManguinhosBastos DS.
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
La Nación, sujeto y objeto del Estado Liberal Español
Historia Contemporánea, 1998 openaire +3 more sources
Fluid management in sepsis: 5 reasons why less fluid might be more rational. [PDF]
Crit Care SciTaniguchi TM, Taniguchi LU.
europepmc +1 more source