Results 91 to 100 of about 103,061 (300)

Perfil das reservas particulares do patrimônio natural do Estado do Paraná

Acta Scientiarum. Agronomy, 2007
As Reservas Particulares do Patrimonio Natural (RPPNs), uma das categorias de manejo do Sistema Nacional de Unidades de Conservacao, sao fundamentais para a preservacao da biodiversidade. Com o objetivo de caracterizar as RPPNs do Estado do Parana, destacando os pontos primordiais para um efetivo e adequado manejo das areas em prol da conservacao ...
Antonio Cristiano Vieira Cegana, Leide Yassuco Takahashi, Leide Yassuco Takahashi, Francisco Giovanni David Vieira, Francisco Giovanni David Vieira   +4 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Preleções sobre Direito Natural e Ciência do Estado de Heidelberg

Revista Ágora Filosófica, 2015
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Georg Wilhelm Hegel (Autor traduzido), Danilo Vaz-Cuarado R. M. Costa   +1 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Aplicação da condutância longitudinal na estimativa da vulnerabilidade natural do sistema aquífero guarani no estado de São Paulo

, 2018
This paper presents the results obtained from geophysical data processing, which were acquired through vertical electrical soundings developed on occurrence area of the Guarani Aquifer System (GAS), in São Paulo state, Brazil. The Institute Technological
Birelli, Carlos Alberto, Blanco, Régis Gonçalves, Braga, Antonio Celso De Oliveira [UNESP], Francisco, Richard Fonseca [UNESP]   +3 more
core   +1 more source

The Germination Performance After Dormancy Breaking of Leucaena diversifolia (Schltdl.) Benth. Seeds in a Thermal Gradient and Its Distribution Under Climate Change Scenarios

Plants
Climate change models predict temperature increases, which may affect germination, an important stage in the recruitment of individuals in agroecosystems.
Andrés Flores, Cesar M. Flores-Ortíz, Patricia D. Dávila-Aranda, Norma Isela Rodríguez-Arévalo, Salvador Sampayo-Maldonado, Daniel Cabrera-Santos, Maraeva Gianella, Tiziana Ulian   +7 more
doaj   +1 more source

Criptococosis. Historia natural y estado actual del tratamiento

, 2005
"La criptococosis es una enfermedad micótica oportunista grave causada por Cryptococcus neoformans un hongo levaduriforme y encapsulado. Sus dos variedades; Cryptococcus neoformans var. neoformans (serotipos A y D) y Cryptococcus neoformans var. gattii (serotipos B y C) son responsables de enfermedad en el hombre. La infección ocurre por inhalación del
Oscar Vázquez Tsuji, Ignacio Martínez Barbabosa, Teresita Campos Rivera   +2 more
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source