Results 191 to 200 of about 1,021,999 (290)

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

IL-33 Elicits LTC₄ Synthesis in Allergic Inflammation via ST2-Mediated Activation of Eosinophils. [PDF]

Eur J Immunol
Rosário-Garcia VF, Guimaraes-Ferreira E, Brito-Leite Y, Oliveira JF, Santos-da-Silva J, Amorim NRT, Muniz VS, Bolini L, Werneck MBF, Canetti C, Diaz BL, Bandeira-Melo C.   +11 more
europepmc   +1 more source

Mulheres viajantes no Estado Novo

, 2022
openaire   +2 more sources

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

Emergence of a novel reassorted high pathogenicity avian influenza A(H5N2) virus associated with severe pneumonia in a young adult. [PDF]

Sci Rep
Vázquez-Pérez JA, Becerril-Vargas E, Ramírez-González JE, Solís-Hernández M, Davis CT, Garciadiego-Fossas P, Villanueva-Reza M, Chávez-Morales HH, Mendoza-Ramírez E, Olivares-Flores CD, Vera-Jiménez AC, Rumbo-Nava U, Guadarrama-Pérez C, Recinos-Carrera EG, Zúñiga J, López-Martínez I, Hernández-Rivas L, Barrera-Badillo G, Colin-Soto N, Flores-Cisneros L, Carbajal-Sandoval G, Vidal-Aguirre D, Arellano-Suarez DS, Aparicio-Antonio R, López-Elizalde R, Alcazar-Ramiro CJ, García-López A, Di H, Kirby M, Jang Y, Lezana-Fernández MA, Hernández-Cárdenas CM.   +31 more
europepmc   +1 more source

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, EarlyView.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

Anti-mycotoxin additive mixture in cattle feed contaminated with multiple mycotoxins: impacts on performance and health. [PDF]

Trop Anim Health Prod
Torteli MA, Brunetto ALR, Mello EP, Deolindo GL, Nora L, Dos Santos TL, Da Gloria EM, Manica D, Bagatini MD, Da Silva AS.   +9 more
europepmc   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

QTL mapping, breeding, and debugging Saccharomyces cerevisiae strains through Reiterated Mass Selection and backcrosSing (ReMaSSing). [PDF]

Biotechnol Biofuels Bioprod
de Bem LS, Barreto JA, de Souza DT, Jordan DO, de Souza SFD, Marin DC, Da Silva JJ, Brienzo M, Dos Santos LV, Rabelo SC, Margarido GA, Gross J, Jacobus AP.   +12 more
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source