Results 211 to 220 of about 4,659,210 (298)

[Temporal trends and clinical-epidemiological profile of visceral leishmaniasis-HIV coinfection in Brazilian states between 2009 and 2024]. [PDF]

Cad Saude Publica
França M, Santos MFDC, Gouveia JG, Antero L.   +3 more
europepmc   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

The Family Health Strategy as a policy of the State: trajectory, institutional capacity and the current primary health care agenda. [PDF]

Cad Saude Publica
Klitzke D.
europepmc   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Draft genome of <i>Streptomyces</i> sp. AM6-12, a putative novel species for drug discovery isolated from Brazilian Restinga coastal soil. [PDF]

Microbiol Resour Announc
Oliveira MU, Serafim da Silva VA, Rangel RR, Nhampossa NA, Amaral JRV, Alviano DS, da Conceição CS, Gonçalves CAX, Squizani ED, da Silva S, Macrae A, do Nascimento RP.   +11 more
europepmc   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Land expropriation, litigation, and reinterpretation of space in the genesis of the zoobotanical park of Museu Paraense Emílio Goeldi, 1895-1941. [PDF]

Hist Cienc Saude Manguinhos
Leal D, Sanjad N.
europepmc   +1 more source

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Detection and characterization of a MERS-related coronavirus (Betacoronavirus cameli) in velvety free-tailed bats (Molossus molossus, Mammalia) captured in Southern Brazil. [PDF]

Braz J Microbiol
Sita A, Filippi M, Comerlato J, Birlem GE, de Souza da Silva D, Mallmann L, de Abreu Góes Pereira VM, Demoliner M, Gularte JS, Hansen AW, Spilki FR, Weber MN.   +11 more
europepmc   +1 more source