Results 211 to 220 of about 1,027,919 (286)

QTL mapping, breeding, and debugging Saccharomyces cerevisiae strains through Reiterated Mass Selection and backcrosSing (ReMaSSing). [PDF]

Biotechnol Biofuels Bioprod
de Bem LS, Barreto JA, de Souza DT, Jordan DO, de Souza SFD, Marin DC, Da Silva JJ, Brienzo M, Dos Santos LV, Rabelo SC, Margarido GA, Gross J, Jacobus AP.   +12 more
europepmc   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Draft genome sequences of <i>Bacillus velezensis</i> and <i>Bacillus subtilis</i> strains with plant growth-promoting and drought resilience potential. [PDF]

Microbiol Resour Announc
Silva Ferreira LV, Gomes de Paula Lana U, Abreu de Oliveira-Paiva C, Aparecida Gomes E, Morais de Sousa Tinoco S.   +4 more
europepmc   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Fluoxetine Reshapes Macrophage Membrane Sphingolipids and Inflammatory Response Without Affecting Extracellular Vesicle Biogenesis upon Inactivated SARS-CoV-2 Stimulation. [PDF]

Membranes (Basel)
de Carvalho JCS, Nobre-Azevedo P, da Silva-Neto PV, Oliveira BTM, Tavares LA, Toro DM, Borges AO, Nascimento MA, Arruda E, Martins RB, Almeida F, Sorgi CA.   +11 more
europepmc   +1 more source

O Fôro no Estado Novo

Revista da Faculdade de Direito, Universidade de São Paulo, 1940
openaire   +2 more sources

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Sleep disturbances associated with <i>DEAF1</i> pathogenic variants. [PDF]

J Clin Sleep Med
Guerreiro P, Moysés-Oliveira M, Paschalidis M, Kloster A, Cunha L, Deconto TB, Mosini AC, Marquezini BP, Adami LNG, Andersen ML, Tufik S.   +10 more
europepmc   +1 more source